ArticleIntensive care medicine2011
Time to generate ventilator-induced lung injury among mammals with healthy lungs: a unifying hypothesis.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Global Protective Ventilator Settings Are Not Regional Protection: A Compartment-Resolved Framework for Personalizing Mechanical Ventilation in Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- Ventilation-perfusion effects of negative-pressure ventilation: insights from an experimental rat model.Intensive care medicine experimental · 2026Article
- Lower tidal volume ventilation post-bilateral lung transplantation is associated with ventilator-free days.Acta anaesthesiologica Scandinavica · 2025Article
- Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data.European journal of medical research · 2024Observational
- Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation.Communications medicine · 2024Article
- Unphysiological lung strain promotes ventilation-induced lung injury via activation of the PECAM-1/Src/STAT3 signaling pathway.Frontiers in pharmacology · 2024Article
- Understanding the mechanisms of ventilator-induced lung injury using animal models.Intensive care medicine experimental · 2023Review
- Risk factors for ventilator-induced-lung injury develop three to five times faster after a single episode of lung injury.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Article
- Effect of Invasive Mechanical Ventilation at Birth on Lung Function Later in Childhood.Frontiers in pediatrics · 2022Article
- Mechanistic Understanding of Lung Inflammation: Recent Advances and Emerging Techniques.Journal of inflammation research · 2022Review
- Mechanical Power: A New Concept in Mechanical Ventilation.The American journal of the medical sciences · 2021Review
- The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome.Respiratory research · 2021Article
- A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase AAntioxidants (Basel, Switzerland) · 2021Article
- Static and Dynamic Contributors to Ventilator-induced Lung Injury in Clinical Practice. Pressure, Energy, and Power.American journal of respiratory and critical care medicine · 2020Review
- Lessons learned in acute respiratory distress syndrome from the animal laboratory.Annals of translational medicine · 2019Review
- Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation.American journal of respiratory cell and molecular biology · 2019Article
- Effects of Protective Mechanical Ventilation With Different PEEP Levels on Alveolar Damage and Inflammation in a Model of Open Abdominal Surgery: A Randomized Study in Obese Versus Non-obese Rats.Frontiers in physiology · 2019Article
- Should we titrate positive end-expiratory pressure based on an end-expiratory transpulmonary pressure?Annals of translational medicine · 2018Article
- Quantification of Age-Related Lung Tissue Mechanics under Mechanical Ventilation.Medical sciences (Basel, Switzerland) · 2017Article
- Respiratory mechanics and lung stress/strain in children with acute respiratory distress syndrome.Annals of intensive care · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate ventilator-induced lung injury (VILI), several experimental models were designed including different mammalian species and ventilator settings, leading to a large variability in the observed time-course and injury severity. We hypothesized that the time-course of VILI may be fully explained from a single perspective when considering the insult actually applied, i.e. lung stress and strain.
methodsStudies in which healthy animals were aggressively ventilated until preterminal VILI were selected via a Medline search. Data on morphometry, ventilator settings, respiratory function and duration of ventilation were derived. For each animal group, lung stress (transpulmonary pressure) and strain (end-inspiratory lung inflation/lung resting volume ratio) were estimated.
resultsFrom the Medline search 20 studies including five mammalian species (sheep, pigs, rabbits, rats, mice) were selected. Time to achieve preterminal VILI varied widely (18-2,784 min), did not correlate with either tidal volume (expressed in relation to body weight) or airway pressure applied, but was weakly associated with lung stress (r (2) = 0.25, p = 0.008). In contrast, the duration of mechanical ventilation was closely correlated with both lung strain (r (2) = 0.85, p < 0.0001) and lung strain weighted for the actual time of application during each breath (r (2) = 0.83, p < 0.0001), according to exponential decay functions. When it was normalized for the lung strain applied, larger species showed a greater resistance to VILI than smaller species (medians, 25th-75th percentiles: 690, 460-2,001 min vs. 16, 4-59 min, respectively; p < 0.001).
conclusionLung strain may play a critical role as a unifying rule describing the development of VILI among mammals with healthy lungs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.