ArticleDiabetologia2012
Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 49 citations in OpenAlex.
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- Is vulnerability to cardiometabolic disease in Indians mediated by abdominal adiposity or higher body adiposity.BMC public health · 2014Article
- Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions.Journal of diabetes research · 2014Review
- Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.Human heredity · 2014Article
- Association study of the ABCC8 gene variants with type 2 diabetes in south Indians.Indian journal of human genetics · 2014Article
- Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups.PloS one · 2013Article
- Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.PloS one · 2013Article
- Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes.PloS one · 2013Article
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22 authors at 5 institutions in 2 countries.
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Abstract
aims/hypothesisEvaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population.
methodsWe genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits.
resultsThe risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 (p = 0.05), 0.01 (p = 0.01), 0.007 (p = 0.05), 0.01 (p = 0.003) and 0.08 (p = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of -0.06 (p = 0.04), 0.05 (p = 0.05), -0.08 (p = 0.01) and -0.08 (p = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2, ADAM30 and CDKN2A/B, with β values of 0.05 (p = 0.04), -0.07 (p = 0.03) and -0.08 (p = 0.02), respectively. We also found significant associations of ADAM30 (β = -0.05; p = 0.01) and CDKN2A/B (β = -0.05; p = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p = 0.03). CONCLUSIONS/
interpretationWe validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification.
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