ArticleJournal of the American Society of Nephrology : JASN2011
AT1 receptors in the collecting duct directly modulate the concentration of urine.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Genomic insights into the convergent evolution of desert adaptation in camels and antelopes.Zoological research · 2025Article
- Renal glomerular and tubular injury in the offspring of the preeclampsia-like syndrome.Scientific reports · 2025Article
- Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake.Journal of the American Society of Nephrology : JASN · 2024Article
- Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial NaHypertension (Dallas, Tex. : 1979) · 2024Article
- Blood pressure effects of sodium transport along the distal nephron.Kidney international · 2022Review
- Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022Review
- Local and downstream actions of proximal tubule angiotensin II signaling on NaAmerican journal of physiology. Renal physiology · 2021Article
- Renin-angiotensin system in mammalian kidney development.Pediatric nephrology (Berlin, Germany) · 2021Review
- Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion.American journal of physiology. Renal physiology · 2018Article
- Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy.American journal of hematology · 2018Article
- Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.Physiological reviews · 2018Review
- Article
- Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport.Journal of the American Society of Nephrology : JASN · 2016Article
- Heterotrimeric G protein signaling in polycystic kidney disease.Physiological genomics · 2016Review
- Role of the Collecting Duct Renin Angiotensin System in Regulation of Blood Pressure and Renal Function.Current hypertension reports · 2016Review
- Potassium and Its Discontents: New Insight, New Treatments.Journal of the American Society of Nephrology : JASN · 2016Review
- Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension.Physiological reports · 2016Article
- Nephron-specific deletion of the prorenin receptor causes a urine concentration defect.American journal of physiology. Renal physiology · 2015Article
- Collecting duct principal cell transport processes and their regulation.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
Mice lacking AT(1) angiotensin receptors have an impaired capacity to concentrate the urine, but the underlying mechanism is unknown. To determine whether direct actions of AT(1) receptors in epithelial cells of the collecting duct regulate water reabsorption, we used Cre-Loxp technology to specifically eliminate AT(1A) receptors from the collecting duct in mice (CD-KOs). Although levels of AT(1A) receptor mRNA in the inner medulla of CD-KO mice were significantly reduced, their kidneys appeared structurally normal. Under basal conditions, plasma and urine osmolalities and urine volumes were similar between CD-KO mice and controls. The increase in urine osmolality in response to water deprivation or vasopressin administration, however, was consistently attenuated in CD-KO mice. Similarly, levels of aquaporin-2 protein in inner and outer medulla after water deprivation were significantly lower in CD-KO mice compared with controls, despite its normal localization to the apical membrane. In summary, these results demonstrate that AT(1A) receptors in epithelial cells of the collecting duct directly modulate aquaporin-2 levels and contribute to the concentration of urine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.