Evidence map›Paper›PMID 22052047›Full record

ReviewJournal of the American Society of Nephrology : JASN2011

Development of the renal arterioles.

Maria Luisa S Sequeira Lopez, R Ariel Gomez

Abstract readReview
In one paragraph

Review in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 146 citations in OpenAlex.

  1. Article
  2. The kidney stroma in development and disease.Nature reviews. Nephrology · 2025
    Review
  3. The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Ocular manifestations in renal diseases.Indian journal of ophthalmology · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Renin Cells, the Kidney, and Hypertension.Circulation research · 2021
    Review
  15. Phylogeny and ontogeny of the renin-angiotensin system: Current view and perspectives.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2021
    Review
  16. Review
  17. Article
  18. Ontogeny of renin gene expression in the chicken, Gallus gallus.General and comparative endocrinology · 2020
    Article
  19. Review
  20. Sox6 as a new modulator of renin expression in the kidney.American journal of physiology. Renal physiology · 2020
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria Luisa S Sequeira LopezUniversity of Virginia School of Medicine, 409 Lane Road, MR4 Building, Room 2001, Charlottesville, VA 22908, USA. msl7u@virginia.edu
R Ariel Gomez
University of Virginia · US

Funding

Renin Cell Fate in the Kidney VasculatureR37HL066242 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2007 to 2016
$4.0M
Development of the Renal ArteriolesR01DK091330 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2011 to 2015
$1.7M
Role of micro RNAs in renin cell differentiationR01HL096735 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2010 to 2013
$1.5M
Development of the renin-expressing cellK08DK075481 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2006 to 2010
$678k
NHLBI NIH HHS R01 HL096735NHLBI NIH HHS R37 HL066242NIDDK NIH HHS K08 DK075481NIDDK NIH HHS K08 DK75481NIDDK NIH HHS R01 DK091330
6 · The paper itself

Abstract

The kidney is a highly vascularized organ that normally receives a fifth of the cardiac output. The unique spatial arrangement of the kidney vasculature with each nephron is crucial for the regulation of renal blood flow, GFR, urine concentration, and other specialized kidney functions. Thus, the proper and timely assembly of kidney vessels with their respective nephrons is a crucial morphogenetic event leading to the formation of a functioning kidney necessary for independent extrauterine life. Mechanisms that govern the development of the kidney vasculature are poorly understood. In this review, we discuss the anatomical development, embryological origin, lineage relationships, and key regulators of the kidney arterioles and postglomerular circulation. Because renal disease is associated with deterioration of the kidney microvasculature and/or the reenactment of embryonic pathways, understanding the morphogenetic events and processes that maintain the renal vasculature may open new avenues for the preservation of renal structure and function and prevent the progression of renal disease.

Indexed as

AnimalsArteriolesHumansKidneyNeovascularization, Physiologic

Identifiers

PMID22052047
PMCPMC3250202
OpenAlexW2152046643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.