ReviewMammalian genome : official journal of the International Mammalian Genome Society2012
Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Incidence of portosystemic shunts in Finnish miniature schnauzer litters.Acta veterinaria Scandinavica · 2026Article
- Primary portal vein hypoplasia in cats: clinical findings, diagnosis and outcomes in five cases.Journal of feline medicine and surgery · 2026Article
- Surgical treatment of concomitant congenital left gastro-azygos and extrahepatic umbilico-caval portosystemic shunts in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Single Posthepatic Portosystemic Shunt Communicated With Internal Thoracic Vein and Azygos Continuation of the Caudal Vena Cava in a Dog.Veterinary medicine and science · 2024Article
- Radiologic Evaluation of Portosystemic Shunts in Humans and Small Animals: Review of the Literature with Clinical Case Reports.Diagnostics (Basel, Switzerland) · 2023Article
- Anomalies of the Portal Venous System in Dogs and Cats as Seen on Multidetector-Row Computed Tomography: An Overview and Systematization Proposal.Veterinary sciences · 2019Review
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- Comparison of contrast-enhanced multidetector computed tomography angiography and splenoportography for the evaluation of portosystemic-shunt occlusion after cellophane banding in dogs.BMC veterinary research · 2016Article
- Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins.Journal of visualized experiments : JoVE · 2016Article
- Spectrum of hepatofugal collateral pathways in portal hypertension: an illustrated radiological review.Insights into imaging · 2015Article
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- Aberrant gene expression in dogs with portosystemic shunts.PloS one · 2013Article
- Distribution of extrahepatic congenital portosystemic shunt morphology in predisposed dog breeds.BMC veterinary research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital disorders of the hepatic portal vasculature are rare in man but occur frequently in certain dog breeds. In dogs, there are two main subtypes: intrahepatic portosystemic shunts, which are considered to stem from defective closure of the embryonic ductus venosus, and extrahepatic shunts, which connect the splanchnic vascular system with the vena cava or vena azygos. Both subtypes result in nearly complete bypass of the liver by the portal blood flow. In both subtypes the development of the smaller branches of the portal vein tree in the liver is impaired and terminal branches delivering portal blood to the liver lobules are often lacking. The clinical signs are due to poor liver growth, development, and function. Patency of the ductus venosus seems to be a digenic trait in Irish wolfhounds, whereas Cairn terriers with extrahepatic portosystemic shunts display a more complex inheritance. The genes involved in these disorders cannot be identified with the sporadic human cases, but in dogs, the genome-wide study of the extrahepatic form is at an advanced stage. The canine disease may lead to the identification of novel genes and pathways cooperating in growth and development of the hepatic portal vein tree. The same pathways likely regulate the development of the vascular system of regenerating livers during liver diseases such as hepatitis and cirrhosis. Therefore, the identification of these molecular pathways may provide a basis for future proregenerative intervention.
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