ArticleMammalian genome : official journal of the International Mammalian Genome Society2012
A genome-wide association study of osteochondritis dissecans in the Thoroughbred.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Heritability and prevalence of selected osteochondrosis lesions in yearling Thoroughbred horses.Equine veterinary journal · 2017Pooled it
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- Haplotype GWAS in Swedish warmblood horses for conformation and jumping traits.Journal of animal science · 2026Article
- Osteochondrosis in horses: An overview of genetic and other factors.Equine veterinary journal · 2026Review
- Common protein-coding variants influence the racing phenotype in galloping racehorse breeds.Communications biology · 2022Article
- Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.Animal genetics · 2019Review
- Differences between horse selection based on two forms of osteochondrosis in fetlock.Journal of applied genetics · 2018Article
- Polymorphisms in ten candidate genes are associated with conformational and locomotive traits in Spanish Purebred horses.Journal of applied genetics · 2017Article
- Developing a 670k genotyping array to tag ~2M SNPs across 24 horse breeds.BMC genomics · 2017Article
- Article
- Risk of false positive genetic associations in complex traits with underlying population structure: a case study.Veterinary journal (London, England : 1997) · 2014Article
- Applied equine genetics.Equine veterinary journal · 2014Review
- Genome-wide analysis of DNA methylation patterns in horse.BMC genomics · 2014Article
- Emerging genetic basis of osteochondritis dissecans.Clinics in sports medicine · 2014Review
- The utility of low-density genotyping for imputation in the Thoroughbred horse.Genetics, selection, evolution : GSE · 2014Article
- Identification of genomic loci associated with Rhodococcus equi susceptibility in foals.PloS one · 2014Article
- Articular osteochondrosis: a comparison of naturally-occurring human and animal disease.Osteoarthritis and cartilage · 2013Review
- Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
Osteochondrosis is a developmental orthopaedic disease that occurs in horses, other livestock species, companion animal species, and humans. The principal aim of this study was to identify quantitative trait loci (QTL) associated with osteochondritis dissecans (OCD) in the Thoroughbred using a genome-wide association study. A secondary objective was to test the effect of previously identified QTL in the current population. Over 300 horses, classified as cases or controls according to clinical findings, were genotyped for the Illumina Equine SNP50 BeadChip. An animal model was first implemented in order to adjust each horse's phenotypic status for average relatedness among horses and other potentially confounding factors which were present in the data. The genome-wide association test was then conducted on the residuals from the animal model. A single SNP on chromosome 3 was found to be associated with OCD at a genome-wide level of significance, as determined by permutation. According to the current sequence annotation, the SNP is located in an intergenic region of the genome. The effects of 24 SNPs, representing QTL previously identified in a sample of Hanoverian Warmblood horses, were tested directly in the animal model. When fitted alongside the significant SNP on ECA3, two of these SNPs were found to be associated with OCD. Confirmation of the putative QTL identified on ECA3 requires validation in an independent sample. The results of this study suggest that a significant challenge faced by equine researchers is the generation of sufficiently large data sets to effectively study complex diseases such as osteochondrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.