ArticleGenome biology and evolution2012
Widespread polymorphism in the positions of stop codons in Drosophila melanogaster.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD.Genetics · 2026Article
- Population Genomics of Premature Termination Codons in Cavefish With Substantial Trait Loss.Molecular biology and evolution · 2025Article
- A Population-Genetic Lens into the Process of Gene Loss Following Whole-Genome Duplication.Molecular biology and evolution · 2022Article
- Article
- Hundreds of Out-of-Frame Remodeled Gene Families in the Escherichia coli Pangenome.Molecular biology and evolution · 2022Article
- Signatures of Relaxed Selection in the CYP8B1 Gene of Birds and Mammals.Journal of molecular evolution · 2019Article
- Are Nonsense Alleles of Drosophila melanogaster Genes under Any Selection?Genome biology and evolution · 2018Article
- Article
- Stop Codon Polymorphisms in the Human SLC9A1 Gene Disrupt or Compromise Na+/H+ Exchanger Function.PloS one · 2016Article
- The Recent De Novo Origin of Protein C-Termini.Genome biology and evolution · 2015Article
- Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis.Genome research · 2015Article
- Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in a Drosophila melanogaster population.Molecular biology and evolution · 2015Article
- Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans.Molecular biology and evolution · 2014Article
- Differential strengths of positive selection revealed by hitchhiking effects at small physical scales in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- The life cycle of Drosophila orphan genes.eLife · 2014Article
- Malaria life cycle intensifies both natural selection and random genetic drift.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- De novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequences.PLoS genetics · 2013Article
- Effects of premature termination codon polymorphisms in the Drosophila pseudoobscura subclade.Journal of molecular evolution · 2012Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying evolutionary changes in protein length are poorly understood. Protein domains are lost and gained between species and must have arisen first as within-species polymorphisms. Here, we use Drosophila melanogaster population genomic data combined with between species divergence information to understand the evolutionary forces that generate and maintain polymorphisms causing changes in protein length in D. melanogaster. Specifically, we looked for protein length variations resulting from premature termination codons (PTCs) and stop codon losses (SCLs). We discovered that 438 genes contained polymorphisms resulting in truncation of the translated region (PTCs) and 119 genes contained polymorphisms predicted to lengthen the translated region (SCLs). Stop codon polymorphisms (SCPs) (especially PTCs) appear to be more deleterious than other polymorphisms, including protein amino acid changes. Genes harboring SCPs are in general less selectively constrained, more narrowly expressed, and enriched for dispensable biological functions. However, we also observed exceptional cases such as genes that have multiple independent SCPs, alleles that are shared between D. melanogaster and Drosophila simulans, and high-frequency alleles that cause extreme changes in gene length. SCPs likely have an important role in the evolution of these genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.