Trial reportThe Journal of allergy and clinical immunology2012
Genome-wide association study reveals class I MHC-restricted T cell-associated molecule gene (CRTAM) variants interact with vitamin D levels to affect asthma exacerbations.
Trial report in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Asthma exacerbations: the Achilles heel of asthma care.Trends in molecular medicine · 2022Review
- The Influence of HLA Alleles on the Affective Distress Profile.International journal of environmental research and public health · 2022Article
- The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations.International journal of molecular sciences · 2021Review
- Acute Severe Asthma in Adolescent and Adult Patients: Current Perspectives on Assessment and Management.Journal of clinical medicine · 2019Review
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma.Chest · 2018Article
- Lessons from ten years of genome-wide association studies of asthma.Clinical & translational immunology · 2017Review
- Genetic Signatures of Asthma Exacerbation.Allergy, asthma & immunology research · 2017Review
- Personalized management of asthma exacerbations: lessons from genetic studies.Expert review of precision medicine and drug development · 2016Article
- CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies.The Journal of allergy and clinical immunology · 2015Article
- Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality.Future virology · 2015Article
- Vitamin D and the development of allergic disease: how important is it?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Review
- Development of a High-resolution Melting Analysis Method Based on SYBR Green-I for rs7216389 Locus Genotyping in Asthmatic Child Patients.Avicenna journal of medical biotechnology · 2014Article
- Peripheral blood T cells and neutrophils from asthma patients express class-I MHC-restricted T cell-associated molecule.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Article
- Review
- Genetics of asthma susceptibility and severity.Clinics in chest medicine · 2012Review
- Vitamin D Insufficiency and Asthma in a US Nationwide Study.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIt has recently been shown that vitamin D deficiency can increase asthma development and severity and that variations in vitamin D receptor genes are associated with asthma susceptibility.
objectiveWe sought to find genetic factors that might interact with vitamin D levels to affect the risk of asthma exacerbation.
methodsWe conducted a genome-wide study of gene-vitamin D interaction on asthma exacerbations using population-based and family-based approaches on 403 subjects and trios from the Childhood Asthma Management Program. Twenty-three polymorphisms with significant interactions were studied in a replication analysis in 584 children from a Costa Rican cohort.
resultsWe identified 3 common variants in the class I MHC-restricted T cell-associated molecule gene (CRTAM) that were associated with an increased rate of asthma exacerbations based on the presence of a low circulating vitamin D level. These results were replicated in a second independent population (unadjusted combined interaction, P = .00028-.00097; combined odds ratio, 3.28-5.38). One variant, rs2272094, is a nonsynonymous coding polymorphism of CRTAM. Functional studies on cell lines confirmed the interaction of vitamin D and rs2272094 on CRTAM expression. CRTAM is highly expressed in activated human CD8(+) and natural killer T cells, both of which have been implicated in asthmatic patients.
conclusionThe findings highlight an important gene-environment interaction that elucidates the role of vitamin D and CD8(+) and natural killer T cells in asthma exacerbation in a genome-wide gene-environment interaction study that has been replicated in an independent population. The results suggest the potential importance of maintaining adequate vitamin D levels in subsets of high-risk asthmatic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.