ArticleLab on a chip2011
Dielectrophoretic tweezers as a platform for molecular force spectroscopy in a highly parallel format.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Beyond the Single Molecule: Multiplexed Methods in Force Spectroscopy.Annual review of biophysics · 2026Review
- Capillary wave tweezer.Scientific reports · 2024Article
- Origami nanogap electrodes for reversible nanoparticle trapping.Nanoscale · 2024Article
- Electromagnetic Forces and Torques: From Dielectrophoresis to Optical Tweezers.Chemical reviews · 2023Review
- Manipulation of single cells via a Stereo Acoustic Streaming Tunnel (SteAST).Microsystems & nanoengineering · 2022Article
- Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device.Sensors (Basel, Switzerland) · 2017Article
- Rotational manipulation of single cells and organisms using acoustic waves.Nature communications · 2016Article
- Size-dependent dielectrophoretic crossover frequency of spherical particles.Biomicrofluidics · 2016Article
- A tapered aluminium microelectrode array for improvement of dielectrophoresis-based particle manipulation.Sensors (Basel, Switzerland) · 2015Article
- Mesenchymal stem cell mechanobiology and emerging experimental platforms.Journal of the Royal Society, Interface · 2013Article
- Progress toward the application of molecular force spectroscopy to DNA sequencing.Electrophoresis · 2012Article
- High density single-molecule-bead arrays for parallel single molecule force spectroscopy.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We demonstrated the application of a simple electrode geometry for dielectrophoresis (DEP) on colloidal probes as a form of molecular force spectroscopy in a highly parallel format. The electric field between parallel plates is perturbed with dielectric microstructures, generating uniform DEP forces on colloidal probes in the range of several hundred piconewtons across a macroscopic sample area. We determined the approximate crossover frequency between negative and positive DEP using electrodes without dielectric microstructures-a simplification over standard experimental methods involving quadrupoles or optical trapping. 2D and 3D simulations of the electric field distributions validated the experimental behavior of several of our DEP tweezers geometries and provided insight into potential improvements. We applied the DEP tweezers to the stretching of a short DNA oligomer and detected its extension using total-internal reflection fluorescence microscopy. The combination of a simple cell fabrication, a uniform distribution of high axial forces, and a facile optical detection of our DEP tweezers makes this form of molecular force spectroscopy ideal for highly parallel detection of stretching or unbinding kinetics of biomolecules.
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Registered trials
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