ArticleJournal of studies on alcohol and drugs2011
Vulnerability to the rapid ("telescoped") development of alcohol dependence in individuals with anxiety disorder.
Article in Journal of studies on alcohol and drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Hybrid cognitive behavioral therapy versus relaxation training for co-occurring anxiety and alcohol disorder: a randomized clinical trial.Journal of consulting and clinical psychology · 2013Trial
- Telescoping phenomenon in pathological gambling: association with gender and comorbidities.The Journal of nervous and mental disease · 2012Trial
- Correlational and causal modeling of alcohol-related symptoms and internalizing disorder status: Further elucidation of a harm paradox.Alcohol, clinical & experimental research · 2025Article
- Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice.bioRxiv : the preprint server for biology · 2025Article
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- Upward social comparison on network and alcohol dependence in college students: the chain mediation impacts of relative deprivation and anxiety.BMC psychology · 2024Article
- Article
- Evidence for an alcohol-related "harm paradox" in individuals with internalizing disorders: Test and replication in two independent community samples.Alcohol, clinical & experimental research · 2023Article
- The direct effect of drinking to cope on alcohol problems is not mediated by alcohol consumption: Invariance across gender and countries.Addictive behaviors reports · 2022Article
- Unraveling the epigenomic and transcriptomic interplay during alcohol-induced anxiolysis.Molecular psychiatry · 2022Article
- Determinants of health-related quality of life in recently detoxified patients with severe alcohol use disorder.Health and quality of life outcomes · 2022Article
- Sex differences in affective states and association with voluntary ethanol intake in Sprague-Dawley rats.Psychopharmacology · 2022Article
- Risk Pathways Contributing to the Alcohol Harm Paradox: Socioeconomic Deprivation Confers Susceptibility to Alcohol DependenceFrontiers in behavioral neuroscience · 2022Article
- Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol.Neuropharmacology · 2020Review
- Chronic Intermittent Ethanol Exposure Selectively Increases Synaptic Excitability in the Ventral Domain of the Rat Hippocampus.Neuroscience · 2019Article
- Co-Occurring Alcohol Use Disorder and Anxiety: Bridging Psychiatric, Psychological, and Neurobiological Perspectives.Alcohol research : current reviews · 2019Review
- Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders.Alcoholism, clinical and experimental research · 2016Review
- Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states.Neuropharmacology · 2015Review
- Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats.Psychopharmacology · 2015Article
- The epigenetic landscape of alcoholism.International review of neurobiology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe frequent co-occurrence of alcohol dependence and anxiety disorder is a long-standing clinical conundrum. An underdeveloped perspective on this issue concerns the impact of a co-occurring anxiety disorder on the sequence and developmental course of alcohol-related milestones. Extrapolating from the body of basic science indicating overlap in the neurobiological processes associated with both anxiety disorder and alcohol dependence-particularly those involving the hypothalamic-pituitary-adrenal axis and elements of the amygdala- we hypothesized that anxiety-disordered individuals are vulnerable to the rapid development of alcohol dependence. Specifically, we predicted that the time from pre-dependence alcohol milestones (e.g., age at which regular drinking began) to post-dependence alcohol milestones would be briefer ("telescoped") among those with an anxiety disorder.
methodSeventy-eight individuals with alcohol dependence who had recently begun a chemical dependency treatment program underwent a diagnostic interview to determine the presence of current anxiety disorders and to establish the age at which several alcohol use and dependence milestones were first achieved.
resultsWe found that, compared with others in the sample, anxiety-disordered individuals transitioned significantly more quickly from the time they first began drinking regularly and first began getting drunk regularly to the onset of alcohol dependence, as well as from most pre-dependence alcohol milestones to the point at which their alcohol dependence was most severe.
conclusionsIndividuals with anxiety disorders transition from regular drinking to alcohol dependence more rapidly than do individuals without anxiety disorders. These findings contribute to an improved understanding of the etiology of comorbidity and suggest novel directions for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.