Trial reportJournal of studies on alcohol and drugs2011
Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans.
Trial report in Journal of studies on alcohol and drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 79 citations in OpenAlex.
- Acute effects of modafinil on brain resting state networks in young healthy subjects.PloS one · 2013Trial
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Genes, Cognition, and Their Interplay in Methamphetamine Use Disorder.Biomolecules · 2025Review
- The use of Modafinil on Methamphetamine withdrawal in mechanically ventilated patients.Respiratory medicine case reports · 2025Article
- Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration.Psychopharmacology · 2024Article
- Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets.Substance abuse and rehabilitation · 2024Review
- Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors.Drug and alcohol dependence · 2023Article
- Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023Article
- Cortical thickness and related depressive symptoms in early abstinence from chronic methamphetamine use.Addiction biology · 2022Article
- Cognition during active methamphetamine use versus remission.Journal of clinical and experimental neuropsychology · 2021Article
- Modafinil reduces smoked cocaine self-administration in humans: effects vary as a function of cocaine 'priming' and cost.Drug and alcohol dependence · 2021Article
- Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?Frontiers in neuroscience · 2021Review
- Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness.Frontiers in neuroscience · 2021Article
- Executive function moderates naltrexone effects on methamphetamine-induced craving and subjective responses.The American journal of drug and alcohol abuse · 2020Article
- Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neurocognitive Dysfunctions and Their Therapeutic Modulation in Patients With Methamphetamine Dependence: A Pilot Study.Frontiers in psychiatry · 2020Article
- Developing neuroscience-based treatments for alcohol addiction: A matter of choice?Translational psychiatry · 2019Review
- Vigilance Decrement and Enhancement Techniques: A Review.Brain sciences · 2019Review
- Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research.Frontiers in psychiatry · 2019Review
- MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.Psychopharmacology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIndividuals who are methamphetamine dependent exhibit higher rates of cognitive dysfunction than healthy people who do not use methamphetamine, and this dysfunction may have a negative effect on the success of behavioral treatments for the disorder. Therefore, a medication that improves cognition, such as modafinil (Provigil), may serve as a useful adjunct to behavioral treatments for methamphetamine dependence. Although cognitive-enhancing effects of modafinil have been reported in several populations, little is known about the effects of modafinil in methamphetamine-dependent individuals. We thus sought to evaluate the effects of modafinil on the cognitive performance of methamphetamine-dependent and healthy individuals.
methodSeventeen healthy subjects and 24 methamphetamine- dependent subjects participated in this randomized, double-blind, placebo-controlled, crossover study. Effects of modafinil (200 mg, single oral dose) were assessed on participants' performance on tests of inhibitory control, working memory, and processing speed/attention.
resultsAcross subjects, modafinil improved performance on a test of sustained attention, with no significant improvement on any other cognitive tests. However, within the methamphetamine-dependent group only, participants with a high baseline frequency of methamphetamine use demonstrated a greater effect of modafinil on tests of inhibitory control and processing speed than those participants with low baseline use of methamphetamine.
conclusionsAlthough modafinil produced limited effects across all participants, methamphetamine-dependent participants with a high baseline use of methamphetamine demonstrated significant cognitive improvement on modafinil relative to those with low baseline methamphetamine use. These results add to the findings from a clinical trial that suggested that modafinil may be particularly useful in methamphetamine-dependent subjects who use the drug frequently.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.