Evidence map›Paper›PMID 22050937›Full record

ReviewPhysical medicine and rehabilitation clinics of North America2011

The pathophysiology of concussions in youth.

Daniel W Shrey, Grace S Griesbach, Christopher C Giza

Abstract readReview
In one paragraph

Review in Physical medicine and rehabilitation clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. An Integrative Review of Return to Driving After Concussion in Adolescents.The Journal of school nursing : the official publication of the National Association of School Nurses · 2021
    Review
  8. Review
  9. Observational
  10. Observational
  11. Visually Evoked Potential Markers of Concussion History in Patients with Convergence Insufficiency.Optometry and vision science : official publication of the American Academy of Optometry · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Office management of mild head injury in children and adolescents.Canadian family physician Medecin de famille canadien · 2014
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel W ShreyDivision of Pediatric Neurology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, Los Angeles, CA 90095, USA. dshrey@mednet.ucla.edu
Grace S Griesbach
Christopher C Giza

Funding

Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
The role of traumatic brain injury stress response on exercise therapyR01NS061960 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRIESBACH, GRACE S. · 2008 to 2012
$1.8M
Restoration of plasticity after pediatric traumatic brain injuryK02NS057420 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GIZA, CHRISTOPHER C · 2007 to 2009
$533k
NINDS NIH HHS K02 NS057420NINDS NIH HHS NS057420NINDS NIH HHS NS06190NINDS NIH HHS NS27544NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS061960
6 · The paper itself

Abstract

Mild traumatic brain injury, especially sport-related concussion, is common among young persons. Consequences of transient pathophysiologic dysfunction must be considered in the context of a developing or immature brain, as must the potential for an accumulation of damage with repeated exposure. This review summarizes the underlying neurometabolic cascade of concussion, with emphasis on the young brain in terms of acute pathophysiology, vulnerability, alterations in plasticity and activation, axonal injury, and cumulative risk from chronic, repetitive damage, and discusses their implications in the context of clinical care for the concussed youth, highlighting areas for future investigation.

Indexed as

AdolescentAnimalsAthletic InjuriesAxonsBrainBrain ConcussionBrain-Derived Neurotrophic FactorBrain Injury, ChronicDementiaHumansReceptors, N-Methyl-D-AspartateRecurrenceSynapsesTime FactorsBrain-Derived Neurotrophic FactorReceptors, N-Methyl-D-Aspartate

Identifiers

PMID22050937
PMCPMC3211100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.