ArticleBMC infectious diseases2011
TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Early changes of the kinetics of monocyte trem-1 reflect final outcome in human sepsis.BMC immunology · 2014Trial
- Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study.Antimicrobial agents and chemotherapy · 2012Trial
- Blood biomarkers in early bacterial infection and sepsis diagnostics in feverish young children.International journal of medical sciences · 2022Article
- Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study.Intensive care medicine · 2022Article
- Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test.Nature communications · 2021Article
- Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness.Malaria journal · 2018Article
- sTREM-1, sIL-2Rα, and IL-6, but not sCD163, might predict sepsis in polytrauma patients: a prospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2017Observational
- Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis.BMC infectious diseases · 2016Article
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Authors and funding
20 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of the causative pathogen in the expression of TREM-1 in sepsis.
methodsPeripheral venous blood was sampled from 125 patients with sepsis and 88 with severe sepsis/septic shock. The causative pathogen was isolated in 91 patients. Patients were suffering from acute pyelonephritis, community-acquired pneumonia (CAP), intra-abdominal infections (IAIs), primary bacteremia and ventilator-associated pneumonia or hospital-acquired pneumonia (VAP/HAP). Blood monocytes and neutrophils were isolated. Flow cytometry was used to estimate the TREM-1 expression from septic patients.
resultsWithin patients bearing intrabdominal infections, expression of TREM-1 was significantly lower on neutrophils and on monocytes at severe sepsis/shock than at sepsis. That was also the case for severe sepsis/shock developed in the field of VAP/HAP. Among patients who suffered infections by Gram-negative community-acquired pathogens or among patients who suffered polymicrobial infections, expression of TREM-1 on monocytes was significantly lower at the stage of severe sepsis/shock than at the stage of sepsis.
conclusionsDecrease of the expression of TREM-1 on the membrane of monocytes and neutrophils upon transition from sepsis to severe sepsis/septic shock depends on the underlying type of infection and the causative pathogen.
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