ArticleJournal of integrative plant biology2011
Subcellular distribution of glutathione precursors in Arabidopsis thaliana.
Article in Journal of integrative plant biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Organelle-specific localization of glutathione in plants grown under different light intensities and spectra.Histochemistry and cell biology · 2022Review
- Metabolism and Regulatory Functions ofFrontiers in plant science · 2021Review
- Compartment specific response of antioxidants to drought stress in Arabidopsis.Plant science : an international journal of experimental plant biology · 2014Article
- Compartment-specific importance of glutathione during abiotic and biotic stress.Frontiers in plant science · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Glutathione is an important antioxidant and has many important functions in plant development, growth and defense. Glutathione synthesis and degradation is highly compartment-specific and relies on the subcellular availability of its precursors, cysteine, glutamate, glycine and γ-glutamylcysteine especially in plastids and the cytosol which are considered as the main centers for glutathione synthesis. The availability of glutathione precursors within these cell compartments is therefore of great importance for successful plant development and defense. The aim of this study was to investigate the compartment-specific importance of glutathione precursors in Arabidopsis thaliana. The subcellular distribution was compared between wild type plants (Col-0), plants with impaired glutathione synthesis (glutathione deficient pad2-1 mutant, wild type plants treated with buthionine sulfoximine), and one complemented line (OE3) with restored glutathione synthesis. Immunocytohistochemistry revealed that the inhibition of glutathione synthesis induced the accumulation of the glutathione precursors cysteine, glutamate and glycine in most cell compartments including plastids and the cytosol. A strong decrease could be observed in γ-glutamylcysteine (γ-EC) contents in these cell compartments. These experiments demonstrated that the inhibition of γ-glutamylcysteine synthetase (GSH1) - the first enzyme of glutathione synthesis - causes a reduction of γ-EC levels and an accumulation of all other glutathione precursors within the cells.
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Registered trials
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