Evidence map›Paper›PMID 22049908›Full record

ArticleAIDS research and human retroviruses2012

Phylogenetic analysis of the Latvian HIV-1 epidemic.

Dace Balode, Helena Skar, Mattias Mild, Tatjana Kolupajeva, Andris Ferdats, Baiba Rozentale, Thomas Leitner, Jan Albert

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Phylodynamic Inference across Epidemic Scales.Molecular biology and evolution · 2017
    Article
  3. Article
  4. The global spread of HIV-1 subtype B epidemic.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016
    Article
  5. Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016
    Review
  6. Observational
  7. Ensuring privacy in the study of pathogen genetics.The Lancet. Infectious diseases · 2014
    Review
  8. Review
  9. Uncovering epidemiological dynamics in heterogeneous host populations using phylogenetic methods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dace BalodeDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Helena Skar
Mattias Mild
Tatjana Kolupajeva
Andris Ferdats
Baiba Rozentale
Thomas Leitner
Jan Albert

Funding

Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
NIAID NIH HHS 5R01AI087520-02NIAID NIH HHS R01 AI087520
6 · The paper itself

Abstract

The Latvian HIV-1 outbreak among intravenous drug users (IDUs) in 1997-1998 involved subtype A1. To obtain a more complete picture of the Latvian HIV-1 epidemic, 315 HIV-1-infected patients diagnosed in 1990-2005 representing different transmission groups and geographic regions were phylogenetically characterized using env V3 and gag p17 sequences. Subtypes A1 and B infections were found in 76% and 22% of the patients, respectively. The subtype A1 sequences formed one large cluster, which also included sequences from other parts of the former Soviet Union (FSU), whereas most subtype B sequences formed three distinct clusters. We estimated that subtype A1 was introduced from FSU around 1997 and initially spread explosively among IDUs in Riga. A recent increase of heterosexually infected persons did not form a separate subepidemic, but had multiple interactions with the IDU epidemic. Subtype B was introduced before the collapse of the Soviet Union and primarily has spread among men who have sex with men.

Indexed as

EpidemicsFemaleHIV-1HIV Envelope Protein gp120HIV InfectionsHumansLatviaMaleMolecular Sequence DataPhylogenySexual BehaviorHIV Envelope Protein gp120

Identifiers

PMID22049908
PMCPMC3399558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.