ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Presynaptic gating of postsynaptically expressed plasticity at mature thalamocortical synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
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- Synaptic plasticity in human thalamocortical assembloids.Cell reports · 2024Article
- Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.bioRxiv : the preprint server for biology · 2024Article
- Synaptic plasticity in human thalamocortical assembloids.bioRxiv : the preprint server for biology · 2024Article
- Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning.Cell reports · 2024Article
- Analyzing the transient response dynamics of long-term depression in the mouse auditory cortexFrontiers in neuroscience · 2024Article
- Article
- Hearing in Complex Environments: Auditory Gain Control, Attention, and Hearing Loss.Frontiers in neuroscience · 2022Review
- Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Presynaptic Inhibitory Effects of Acetylcholine in the Hippocampus: A 40-Year Evolution of a Serendipitous Finding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents.Frontiers in neural circuits · 2020Review
- Selective Strengthening of Intracortical Excitatory Input Leads to Receptive Field Refinement during Auditory Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Rejuvenation of plasticity in the brain: opening the critical period.Current opinion in neurobiology · 2019Review
- Visual deprivation independent shift of ocular dominance induced by cross-modal plasticity.PloS one · 2019Article
- Adenosine AAnatomical record (Hoboken, N.J. : 2007) · 2018Article
- Control of synaptic plasticity in deep cortical networks.Nature reviews. Neuroscience · 2018Review
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Thalamocortical (TC) projections provide the major pathway for ascending sensory information to the mammalian neocortex. Arrays of these projections form synaptic inputs on thalamorecipient neurons, thus contributing to the formation of receptive fields (RFs) in sensory cortices. Experience-dependent plasticity of RFs persists throughout an organism's life span but in adults requires activation of cholinergic inputs to the cortex. In contrast, synaptic plasticity at TC projections is limited to the early postnatal period. This disconnect led to the widespread belief that TC synapses are the principal site of RF plasticity only in neonatal sensory cortices, but that they lose this plasticity upon maturation. Here, we tested an alternative hypothesis that mature TC projections do not lose synaptic plasticity but rather acquire gating mechanisms that prevent the induction of synaptic plasticity. Using whole-cell recordings and direct measures of postsynaptic and presynaptic activity (two-photon glutamate uncaging and two-photon imaging of the FM 1-43 assay, respectively) at individual synapses in acute mouse brain slices that contain the auditory thalamus and cortex, we determined that long-term depression (LTD) persists at mature TC synapses but is gated presynaptically. Cholinergic activation releases presynaptic gating through M(1) muscarinic receptors that downregulate adenosine inhibition of neurotransmitter release acting through A(1) adenosine receptors. Once presynaptic gating is released, mature TC synapses can express LTD postsynaptically through group I metabotropic glutamate receptors. These results indicate that synaptic plasticity at TC synapses is preserved throughout the life span and, therefore, may be a cellular substrate of RF plasticity in both neonate and mature animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.