ArticleProceedings of the National Academy of Sciences of the United States of America2011
Alternatively spliced domains interact to regulate BK potassium channel gating.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Larval exposure to sertraline induces dose- and time-dependent remodeling of neuronal alternative splicing in adult Drosophila melanogaster.Molecular biology reports · 2026Article
- Conserved Calcineurin A splice variants regulate both constitutive and experience-dependent behaviors through tissue-specific signaling.PLoS genetics · 2025Article
- Detecting gene expression in Caenorhabditis elegans.Genetics · 2025Review
- Thermal acclimation and habitat-dependent differences in temperature robustness of a crustacean motor circuit.Frontiers in cellular neuroscience · 2023Article
- Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- Article
- A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo.The Journal of pharmacology and experimental therapeutics · 2018Article
- Article
- Behavioral Deficits Following Withdrawal from Chronic Ethanol Are Influenced by SLO Channel Function inGenetics · 2017Article
- Understanding the conformational motions of RCK gating rings.The Journal of general physiology · 2017Review
- A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus.Scientific reports · 2017Article
- ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response ineLife · 2017Article
- Putative calcium-binding domains of the Caenorhabditis elegans BK channel are dispensable for intoxication and ethanol activation.Genes, brain, and behavior · 2015Article
- The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.PLoS neglected tropical diseases · 2015Article
- Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.PLoS neglected tropical diseases · 2014Article
- Nematodes feel a craving--using Caenorhabditis elegans as a model to study alcohol addiction.Neuroscience bulletin · 2014Review
- Conserved single residue in the BK potassium channel required for activation by alcohol and intoxication in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The multiplicity of alternative splicing decisions in Caenorhabditis elegans is linked to specific intronic regulatory motifs and minisatellites.BMC genomics · 2014Article
- Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.Frontiers in physiology · 2014Review
- The regulation of BK channel activity by pre- and post-translational modifications.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Most human genes contain multiple alternative splice sites believed to extend the complexity and diversity of the proteome. However, little is known about how interactions among alternative exons regulate protein function. We used the Caenorhabditis elegans slo-1 large-conductance calcium and voltage-activated potassium (BK) channel gene, which contains three alternative splice sites (A, B, and C) and encodes at least 12 splice variants, to investigate the functional consequences of alternative splicing. These splice sites enable the insertion of exons encoding part of the regulator of K(+) conductance (RCK)1 Ca(2+) coordination domain (exons A1 and A2) and portions of the RCK1-RCK2 linker (exons B0, B1, B2, C0, and C1). Exons A1 and A2 are used in a mutually exclusive manner and are 67% identical. The other exons can extend the RCK1-RCK2 linker by up to 41 residues. Electrophysiological recordings of all isoforms show that the A1 and A2 exons regulate activation kinetics and Ca(2+) sensitivity, but only if alternate exons are inserted at site B or C. Thus, RCK1 interacts with the RCK1-RCK2 linker, and the effect of exon variation on gating depends on the combination of alternate exons present in each isoform.
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Registered trials
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