ArticleResearch in pharmaceutical sciences2011
Effects of extract and essential oil of Rosmarinus officinalis L. on TNBS-induced colitis in rats.
Article in Research in pharmaceutical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Evaluation of the Safety and Antiproliferative Activity of Bulgarian Rose Essential Oil: An In Vitro and In Silico Model of Colorectal Adenocarcinoma.Current issues in molecular biology · 2025Article
- Biosynthesis of palladium, platinum, and their bimetallic nanoparticles using rosemary and ginseng herbal plants: evaluation of anticancer activity.Scientific reports · 2024Article
- Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review.Molecules (Basel, Switzerland) · 2023Review
- RETRACTED: The Synergistic Hepatoprotective Activity of Rosemary Essential Oil and Curcumin: The Role of the MEK/ERK Pathway.Molecules (Basel, Switzerland) · 2022Article
- Ulcer-Healing Effect of Hydroalcoholic Extract and Essential Oil ofInternational journal of preventive medicine · 2022Article
- Anti-inflammatory effect ofResearch in pharmaceutical sciences · 2021Article
- Traditional medicinal knowledge of plants used for cancer treatment by communities of mountainous areas of Fez-Meknes-Morocco.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
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- Rosemary (International journal of nutrition · 2021Article
- Full-Spectrum Analysis of Bioactive Compounds in Rosemary (Molecules (Basel, Switzerland) · 2020Article
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- Iranian Medicinal Plants: From Ethnomedicine to Actual Studies.Medicina (Kaunas, Lithuania) · 2020Review
- Simultaneous GC-FID Quantification of Main Components ofJournal of analytical methods in chemistry · 2019Article
- Anti-inflammatory effect of apigenin and hydroalcoholic extract ofResearch in pharmaceutical sciences · 2017Article
- Chemotypic Characterization and Biological Activity of Rosmarinus officinalis.Foods (Basel, Switzerland) · 2017Article
- The Neuroprotective Effect of Rosemary (Iranian journal of pharmaceutical research : IJPR · 2016Article
- Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Essential oils purified from Schisandrae semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells.BMC complementary and alternative medicine · 2015Article
- Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice.International journal of preventive medicine · 2014Article
- Beneficial Effects of Maprotiline in a Murine Model of Colitis in Normal and Reserpinised Depressed Rats.International scholarly research notices · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosmarinus officinalis L. (Family Lamiaceae) popularly named rosemary, is a common household plant grown around the world, including Iran. Rosemary aerial parts are used as flavoring agent in foods, beverages, and cosmetic preparations and have various traditional uses in ethnomedicine including: analgesic, anti-inflammatory, anti-rheumatic, spasmolytic, carminative and choleretic applications. This study was carried out to investigate the effects of rosemary leaves hydroalcoholic extract (RHE) and essential oil (REO) in a well-defined model of experimental colitis induced by trinitrobenzene sulfonic acid (TNBS) in rats. Different doses of RHE (100, 200 and 400 mg/kg) and REO (100, 200 and 400 μl/kg) were administered orally and intraperitoneally (100, 400 mg/kg and 100, 400 μl/kg) to male Wistar rats (n=6), 6 h after colitis induction and continued for 5 days by intracolonic instillation of 0.25 ml TNBS (80 mg/kg)/ethanol 50% v/v. Wet colon weight/length ratio was measured and tissue damage scores as well as indices of colitis were evaluated both macroscopically and histopathologically. RHE and REO at all test doses used were effective to reduce colon tissue lesions and colitis indices while greater doses were significantly effective to diminish histopathologic parameters irrespective to the route of administration. Administration of oral prednisolone, Asacol(®) (mesalazine microgranules) and parenteral hydrocortisone acetate were effective to reduce colon tissue injures as well. These data suggest that RHE and REO are both effective to possess anti-colitic activity, and reinforce the use of this plant as a remedy for inflammatory bowel diseases in traditional medicine.
Indexed as
Identifiers
22049274PMC3203268W1950488612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.