ArticleAmerican journal of physiology. Cell physiology2012
Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding.
Article in American journal of physiology. Cell physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet.Frontiers in cell and developmental biology · 2023Article
- Ion Transport and Radioresistance.Reviews of physiology, biochemistry and pharmacology · 2022Review
- Ion Channels in Glioma Malignancy.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Role of KCa3.1 Channels in Modulating CaInternational journal of molecular sciences · 2018Review
- Article
- Suppression of CLC-3 chloride channel reduces the aggressiveness of glioma through inhibiting nuclear factor-κB pathway.Oncotarget · 2017Article
- Tweety-Homolog 1 Drives Brain Colonization of Gliomas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.Cell cycle (Georgetown, Tex.) · 2016Article
- KEuropean biophysics journal : EBJ · 2016Review
- A role for ion channels in perivascular glioma invasion.European biophysics journal : EBJ · 2016Review
- Seizures and gliomas--towards a single therapeutic approach.Nature reviews. Neurology · 2016Review
- SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma.Science translational medicine · 2015Article
- Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia?Frontiers in pharmacology · 2015Article
- Article
- Autocrine regulation of glioma cell proliferation via pHe-sensitive K(+) channels.American journal of physiology. Cell physiology · 2014Article
- Calcium entry via TRPC1 channels activates chloride currents in human glioma cells.Cell calcium · 2013Article
- Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Unique biology of gliomas: challenges and opportunities.Trends in neurosciences · 2012Review
- Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.Genes & development · 2012Article
- Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.Journal of signal transduction · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
"Mitotic cell rounding" describes the rounding of mammalian cells before dividing into two daughter cells. This shape change requires coordinated cytoskeletal contraction and changes in osmotic pressure. While considerable research has been devoted to understanding mechanisms underlying cytoskeletal contraction, little is known about how osmotic gradients are involved in cell division. Here we describe cytoplasmic condensation preceding cell division, termed "premitotic condensation" (PMC), which involves cells extruding osmotically active Cl(-) via ClC-3, a voltage-gated channel/transporter. This leads to a decrease in cytoplasmic volume during mitotic cell rounding and cell division. Using a combination of time-lapse microscopy and biophysical measurements, we demonstrate that PMC involves the activation of ClC-3 by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in human glioma cells. Knockdown of endogenous ClC-3 protein expression eliminated CaMKII-dependent Cl(-) currents in dividing cells and impeded PMC. Thus, kinase-dependent changes in Cl(-) conductance contribute to an outward osmotic pressure in dividing cells, which facilitates cytoplasmic condensation preceding cell division.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.