Evidence map›Paper›PMID 22049168›Full record

ArticleThe American journal of clinical nutrition2011

Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.

Rania A Mekary, Eric B Rimm, Edward Giovannucci, Meir J Stampfer, Walter C Willett, David S Ludwig, Frank B Hu

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  11. Red Wine Consumption and Cardiovascular Health.Molecules (Basel, Switzerland) · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rania A MekaryDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Eric B Rimm
Edward Giovannucci
Meir J Stampfer
Walter C Willett
David S Ludwig
Frank B Hu
Harvard University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
Effects of Diet on Hormones, Metabolism and Body WeightK24DK082730 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LUDWIG, DAVID S · 2009 to 2018
$1.6M
NCI NIH HHS CA87969NIDDK NIH HHS DK58845NIDDK NIH HHS K24DK082730NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK46200
6 · The paper itself

Abstract

backgroundLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D).

objectiveThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women.

designParticipants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates.

resultsWe documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to <5 g/d, 1.34 (95% CI: 0.93, 1.92; P-trend = 0.05) in women with alcohol intakes of 5 to <15 g/d, and 0.99 (95% CI: 0.60, 1.65; P-trend = 0.82) in women with alcohol intakes ≥15 g/d (P-interaction = 0.02). However, a higher intake of alcohol did not modify the positive association between GI and T2D (P-interaction = 0.76).

conclusionOur findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence.

Indexed as

Glycemic IndexAdultAlcohol DrinkingBlood GlucoseDiabetes Mellitus, Type 2Dietary CarbohydratesDiet SurveysEthanolFemaleFollow-Up StudiesHumansIncidenceLongitudinal StudiesMiddle AgedProportional Hazards ModelsSurveys and QuestionnairesBlood GlucoseDietary CarbohydratesEthanol

Identifiers

PMID22049168
PMCPMC3252550
OpenAlexW2138598571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.