ArticleThe Journal of general virology2012
Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis.
Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.Frontiers in immunology · 2021Article
- Innate Intracellular Antiviral Responses Restrict the Amplification of Defective Virus Genomes of Parainfluenza Virus 5.Journal of virology · 2020Article
- Review
- Discrimination of Self and Non-Self Ribonucleic Acids.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2017Review
- Single-cell studies of IFN-β promoter activation by wild-type and NS1-defective influenza A viruses.The Journal of general virology · 2017Article
- Bluetongue Virus NS4 Protein Is an Interferon Antagonist and a Determinant of Virus Virulence.Journal of virology · 2016Article
- High-Throughput Single-Cell Kinetics of Virus Infections in the Presence of Defective Interfering Particles.Journal of virology · 2016Article
- Influenza virus activation of the interferon system.Virus research · 2015Review
- Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export.Journal of virology · 2014Article
- In vitro inhibition of mumps virus by retinoids.Virology journal · 2013Article
- Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction.Journal of virology · 2013Article
- RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila.Nature immunology · 2013Article
- Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling.Cell host & microbe · 2013Article
- STAT2 deficiency and susceptibility to viral illness in humans.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.PloS one · 2013Article
- Article
- ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis.The Journal of general virology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-β promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.