ArticleScience translational medicine2011
Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.
Article in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers, 6 of them syntheses that pooled it.
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Who cites it
225 citing papers in PubMed, 6 syntheses or guidelines pooled it, 434 citations in OpenAlex.
- Prevalence of fatty pancreas and its associations with pancreatic disease and metabolic disorders: a systematic review and meta-analysis of 124 studies.Frontiers in nutrition · 2026Pooled it
- Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.Science advances · 2021Pooled it
- Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research.Frontiers in physiology · 2020Pooled it
- The effect of serum triglyceride concentration on the outcome of acute pancreatitis: systematic review and meta-analysis.Scientific reports · 2018Pooled it
- Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.The Journal of clinical investigation · 2020Trial
- Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation.The American journal of pathology · 2014Trial
- A prognostic model based on metabolic indicators for recurrent acute pancreatitis in hypertriglyceridemia patients: a retrospective cohort study.Annals of medicine · 2026Article
- Fatty Pancreas and the Association Between Pancreatic Manipulation Burden and Post-ERCP Pancreatitis.Digestive diseases and sciences · 2026Article
- Intrapancreatic Fat and Risk of Pancreatic Ductal Adenocarcinoma-Pathophysiology, Clinical Implications, and Future Directions.International journal of molecular sciences · 2026Review
- Integrated Transcriptomics and Lipidomics Identify CES1-Mediated Maladaptive Lipolysis as a Key Target of Hyperlipidemic Acute Pancreatitis.Metabolites · 2026Article
- Incidence and Predictors of Acute Pancreatitis in Patients With Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS): A Multicenter Retrospective Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026Article
- A Case of Familial Chylomicronemia Syndrome Caused by a Novel Homozygous GPIHBP1 Mutation Successfully Treated with the Selective PPARα Modulator Pemafibrate.Journal of atherosclerosis and thrombosis · 2026Article
- Rhein alleviates acute pancreatitis by inhibiting TMAO-mediated inflammatory signaling pathways and reducing acinar cell injury.Journal of advanced research · 2026Article
- MASLD and Pancreatic Diseases: From Shared Mechanisms to Clinical Implications and Future Directions.Nutrients · 2026Review
- Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus.Nature reviews. Gastroenterology & hepatology · 2026Review
- ILC2s regulate a fibroblast progenitor niche in the pancreas.Science (New York, N.Y.) · 2026Article
- Obesity suppresses neutrophil-dependent itaconate signaling promoting ferroptosis in acute pancreatitis.Redox biology · 2026Article
- Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non-Hypertriglyceridemia Acute Pancreatitis: A Retrospective Case-Control Study.Health science reports · 2026Article
165 more citing papers are in PubMed but not listed here.
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18 authors at 1 institution in 1 country.
Funding
Abstract
Obesity increases the risk of adverse outcomes during acute critical illnesses such as burns, severe trauma, and acute pancreatitis. Although individuals with more body fat and higher serum cytokines and lipase are more likely to experience problems, the roles that these characteristics play are not clear. We used severe acute pancreatitis as a representative disease to investigate the effects of obesity on local organ function and systemic processes. In obese humans, we found that an increase in the volume of intrapancreatic adipocytes was associated with more extensive pancreatic necrosis during acute pancreatitis and that acute pancreatitis was associated with multisystem organ failure in obese individuals. In vitro studies of pancreatic acinar cells showed that unsaturated fatty acids were proinflammatory, releasing intracellular calcium, inhibiting mitochondrial complexes I and V, and causing necrosis. Saturated fatty acids had no such effects. Inhibition of lipolysis in obese (ob/ob) mice with induced pancreatitis prevented a rise in serum unsaturated fatty acids and prevented renal injury, lung injury, systemic inflammation, hypocalcemia, reduced pancreatic necrosis, and mortality. Thus, therapeutic approaches that target unsaturated fatty acid-mediated lipotoxicity may reduce adverse outcomes in obese patients with critical illnesses such as severe acute pancreatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.