ArticleThe American journal of tropical medicine and hygiene2011
A comparative study of hepatitis caused by scrub typhus and viral hepatitis A in South Korea.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Application of artificial intelligence models in the identification of severe scrub typhus.Frontiers in artificial intelligence · 2026Article
- Acute hepatitis in tropics: A rainbow of causes.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Scrub typhus: risks, diagnostic issues, and management challenges.Research and reports in tropical medicine · 2017Review
- Dissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus.PLoS neglected tropical diseases · 2014Article
- Scrub typhus meningitis or meningoencephalitis.The American journal of tropical medicine and hygiene · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared clinical features and laboratory findings of 104 patients with hepatitis A and 197 patients with scrub typhus. Nausea, vomiting, abdominal pain, hepatomegaly, and jaundice were common in patient with hepatitis A, and fever and headache were significantly more common in patients with scrub typhus. At presentation, an alanine aminotransferase (ALT) level ≥ 500 U/L was observed in 1% of scrub typhus patients and in 87.5% of hepatitis A patients (P < 0.001). A bilirubin level ≥ 1.3 mg/dL was observed in 16.8% of scrub typhus patients and 90.4% of hepatitis A patients. The ALT:lactate dehydrogenase ratio was ≤ 5 in 97.4% of the patients with scrub typhus and > 5 in 95.2% of those with hepatitis A (P < 0.001). Fever, headache, rash, and eschar are findings that indicate scrub typhus. An ALT level ≥ 500 U/L (adjusted odds ratio = 0.011) a bilirubin level ≥ 1.3 (adjusted odds ratio = 0.024), an ALT:lactate dehydrogenase ratio > 5, and hepatomegaly are indications of viral hepatitis A.
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Registered trials
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