Evidence map›Paper›PMID 22048906›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2011

Effects of walnuts (Juglans regia) on learning and memory functions.

Saida Haider, Zehra Batool, Saiqa Tabassum, Tahira Perveen, Sadia Saleem, Fizza Naqvi, Huma Javed, Darakhshan J Haleem

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04075448 (The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04075448 nacompletednot on this mapstarted 2019, after this paper: background citation

The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults

TypeinterventionalSponsorUniversity of ReadingRan2019 to 2020Enrolled32ConditionsCognitive Change, Mood, Inflammatory Response, Brain Derived Neurotrophic Factor LevelArmsControl, 50 g Walnut
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Dietary antioxidants, cognitive function and dementia--a systematic review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2013
    Pooled it
  2. Life (Basel, Switzerland) · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage.Plant foods for human nutrition (Dordrecht, Netherlands) · 2017
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Saida HaiderNeurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan. saida-h1@hotmail.com
Zehra Batool
Saiqa Tabassum
Tahira Perveen
Sadia Saleem
Fizza Naqvi
Huma Javed
Darakhshan J Haleem
University of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Walnut has been regarded as a health food that is delicious and nutritious. Both preventive and therapeutic effects of walnut are well documented. Walnuts are rich in omega-3 fatty acids that are reported to have beneficial effects on brain function. The present work was designed to evaluate the effects of walnuts on learning and memory in male rats. The effect of oral intake of walnut was also monitored on food intake. Walnut was given orally to rats for a period of 28 days. Memory function in rats was assessed by elevated plus maze (EPM) and radial arm maze (RAM). A significant improvement in learning and memory of walnut treated rats compared to controls was observed. Walnut treated rats also exhibited a significant decrease in food intake while the change in growth rate (in terms of percentage) remained comparable between the two groups. Analysis of brain monoamines exhibited enhanced serotonergic levels in rat brain following oral intake of walnuts. The findings suggest that walnut may exert its hypophagic and nootropic actions via an enhancement of brain 5-HT metabolism.

Indexed as

Administration, OralAnimalsBody WeightBrainEatingJuglansMaleMaze LearningMemoryNervous SystemNootropic AgentsRatsRats, WistarSerotoninTryptophanNootropic AgentsSerotoninTryptophan

Identifiers

PMID22048906
OpenAlexW1979236839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.