ArticleMedicine, health care, and philosophy2013
Much more than a gene: hereditary breast and ovarian cancer, reproductive choices and family life.
Article in Medicine, health care, and philosophy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The attitudes of individuals with or at risk of adult-onset genetic conditions on reproductive genetic testing: A systematic review.Journal of genetic counseling · 2025Pooled it
- Familial breast cancer: less emotional distress in adult daughters if they provide emotional support to their affected mother.Familial cancer · 2012Trial
- Identification and management of genetic susceptibility to cancer: UK perspective.BMJ oncology · 2026Review
- "To have children or not?" Between desire, responsibility, luck, and guilt: reproductive decision-making in individuals with neurofibromatosis type 1.Orphanet journal of rare diseases · 2025Article
- Acceptability of the ePOWER intervention: Managing previvors' cancer-related uncertainty and supporting decision making.PEC innovation · 2025Article
- Reproductive decision-making for Barth syndrome carriers: Unexplored complexities.Journal of genetic counseling · 2025Article
- Attitudes toward genetic testing, family planning and preimplantation genetic testing in families with a germline CDKN2A pathogenic variant.Familial cancer · 2024Article
- Knowledge, acceptability and personal attitude toward pre-implantation 1 genetic testing (PGT) and pre-natal diagnosis (PND) for females carrying BRCA pathogenic variant according to fertility preservation experience.Journal of assisted reproduction and genetics · 2023Article
- Review
- BRCA1/2 pathogenetic variant carriers and reproductive decisions: Gender differences and factors associated with the choice of preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND).Journal of assisted reproduction and genetics · 2022Review
- "The Continuous Shadow of My Mother's Breast Cancer": exploring the voice of daughters.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Reproductive decision-making in the context of hereditary cancer: the effects of an online decision aid on informed decision-making.Journal of community genetics · 2021Article
- ART with PGD: Risky heredity and stratified reproduction.Reproductive biomedicine & society online · 2020Article
- Online decision support for persons having a genetic predisposition to cancer and their partners during reproductive decision-making.Journal of genetic counseling · 2019Article
- Article
- The development of an online decision aid to support persons having a genetic predisposition to cancer and their partners during reproductive decision-making: a usability and pilot study.Familial cancer · 2019Article
- Reproductive Decision Support: Preferences and Needs of Couples at Risk for Hereditary Cancer and Clinical Geneticists.Journal of genetic counseling · 2018Article
- Reproductive Decision-Making in Women with BRCA1/2 Mutations.Journal of genetic counseling · 2017Article
- Our genes, our selves: hereditary breast cancer and biological citizenship in Norway.Medicine, health care, and philosophy · 2017Article
- On prenatal diagnosis and the decision to continue or terminate a pregnancy in France: a clinical ethics study of unknown moral territories.Medicine, health care, and philosophy · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents the results of a study that investigates the way in which carriers of a mutation on the BRCA1 or the BRCA2 gene, associated with a high risk of breast and ovarian cancer, make their reproductive decisions. Using semi-structured interviews, the study explored the way in which these persons reflected on the acceptability of taking the risk of transmitting this mutation to the next generation, the arguments they used in favor or against taking that risk, and in the light of these arguments, their opinion on the acceptability of preimplantation genetic diagnosis (PGD) as a reproductive option. The findings suggest that when carriers are planning to have a(nother) child, they are mainly concerned by the risk of transmitting 'much more than a gene': essentially painful experiences not only with respect to health, such as undergoing cancer surveillance or combatting one's own illness, but also with regards to family life, such as witnessing the illness and death of a close relative, encountering difficulties in finding a partner or reconsidering one's plans to have a family. As for opinions concerning the acceptability of PGD as a reproductive option, opinions about personal recourse were varied but all expressed the understanding that PGD should be made available to those persons who consider it their best option.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.