ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Group 2 innate lymphoid cells support hematopoietic recovery under stress conditions.The Journal of experimental medicine · 2021Article
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- Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia.Frontiers in immunology · 2020Article
- Interleukin-33 and ST2 Signaling in Tumor Microenvironment.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2019Review
- Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis.Allergy, asthma & immunology research · 2018Review
- Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven eosinophilia.Immunology · 2018Article
- Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- IL-33 inhibits the differentiation and immunosuppressive activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.Immunology and cell biology · 2017Article
- IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.Nature immunology · 2016Article
- Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients.Cancer immunology, immunotherapy : CII · 2015Article
- Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis.Current opinion in hematology · 2015Review
- Mast cells mediate malignant pleural effusion formation.The Journal of clinical investigation · 2015Article
- Enhanced innate type 2 immune response in peripheral blood from patients with asthma.The Journal of allergy and clinical immunology · 2014Article
- Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations.Journal of leukocyte biology · 2014Review
- Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.The Journal of allergy and clinical immunology · 2014Article
- Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity.Science (New York, N.Y.) · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
IL-33 promotes type 2 immune responses, both protective and pathogenic. Recently, targets of IL-33, including several newly discovered type 2 innate cells, have been characterized in the periphery. In this study, we report that bone marrow cells from wild-type C57BL/6 mice responded with IL-5 and IL-13 production when cultured with IL-33. IL-33 cultures of bone marrow cells from Rag1 KO and Kit(W-sh/W-sh) mice also responded similarly; hence, eliminating the possible contributions of T, B, and mast cells. Rather, intracellular staining revealed that the IL-5- and IL-13-positive cells display a marker profile consistent with the Lineage(-)Sca-1(+)c-Kit(-)CD25(+) (LSK(-)CD25(+)) cells, a bone marrow cell population of previously unknown function. Freshly isolated LSK(-)CD25(+) cells uniformly express ST2, the IL-33 receptor. In addition, culture of sorted LSK(-)CD25(+) cells showed that they indeed produce IL-5 and IL-13 when cultured with IL-33 plus IL-2 and IL-33 plus IL-7. Furthermore, i.p. injections of IL-33 or IL-25 into mice induced LSK(-)CD25(+) cells to expand, in both size and frequency, and to upregulate ST2 and α(4)β(7) integrin, a mucosal homing marker. Thus, we identify the enigmatic bone marrow LSK(-)CD25(+) cells as IL-33 responsive, both in vitro and in vivo, with attributes similar to other type 2 innate cells described in peripheral tissues.
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