ReviewHuman genetics2012
Genetics of GABAergic signaling in nicotine and alcohol dependence.
Review in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Exploratory Analysis of Genetic Variants in BDNF, GABA Receptors, and Dopaminergic Pathways with Alcohol Use Disorder in a Spanish Cohort.International journal of molecular sciences · 2026Article
- Disruption ofiScience · 2026Article
- Transcriptomic signatures in tetrapartite brain region identifies shared and unique gene signatures for substance-use.Frontiers in cellular neuroscience · 2026Article
- Simultaneous selection of multiple important single nucleotide polymorphisms in familial genome wide association studies data.Scientific reports · 2023Article
- Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid overdose.Molecular psychiatry · 2022Article
- Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.BMC medical genomics · 2021Article
- Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder.The international journal of neuropsychopharmacology · 2021Article
- Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.Frontiers in psychiatry · 2018Article
- The influence of adolescent nicotine exposure on ethanol intake and brain gene expression.PloS one · 2018Article
- Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Molecular psychiatry · 2016Review
- Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?Frontiers in cellular neuroscience · 2016Review
- The media and behavioral genetics: Alternatives coexisting with addiction genetics.Science, technology & human values · 2015Article
- Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse.Journal of child psychology and psychiatry, and allied disciplines · 2014Article
- Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample.Alcoholism, clinical and experimental research · 2014Article
- Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants.Molecular neurobiology · 2014Review
- Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells.Neuroscience letters · 2013Article
- Depressive symptoms among heavy cigarette smokers: the influence of daily rate, gender, and race.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Article
- Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat.PloS one · 2013Article
- Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: a meta-analysis.In silico pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Both nicotine and alcohol addictions are common chronic brain disorders that are of great concern to individuals and society. Although genetics contributes significantly to these disorders, the susceptibility genes and variants underlying them remain largely unknown. Many years of genome-wide linkage and association studies have implicated a number of genes and pathways in the etiology of nicotine and alcohol addictions. In this communication, we focus on current evidence, primarily from human genetic studies, supporting the involvement of genes and variants in the GABAergic signaling system in the etiology of nicotine dependence and alcoholism based on linkage, association, and gene-by-gene interaction studies. Current efforts aim not only to replicate these findings in independent samples, but also to identify which variant contributes to the detected associations and through what molecular mechanisms.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.