Evidence map›Paper›PMID 22048712›Full record

Trial reportJournal of human hypertension2012

The effect of 4 weeks of aerobic exercise on vascular and baroreflex function of young men with a family history of hypertension.

M J Goldberg, S H Boutcher, Y N Boutcher

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of human hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Standard Deviation of Individual Response for VOSports medicine (Auckland, N.Z.) · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Article
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  17. Dependency Structures in Differentially Coded Cardiovascular Time Series.Computational and mathematical methods in medicine · 2017
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M J GoldbergUniversity of New South Wales, Sydney, New South Wales, Australia.
S H Boutcher
Y N Boutcher

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of short-term aerobic exercise on vascular function of young individuals with a family history of hypertension was investigated. Thirty young men with a family history of hypertension were randomly assigned to either an exercise (n=15) or control (n=15) group. Exercise subjects performed 30 min of supervised cycle training at 65% of their maximal oxygen uptake (VO(2max)), three times per week for 4 weeks. Control subjects were asked to maintain their normal levels of physical activity. Peak leg and forearm blood flow were assessed using plethysmography and was determined as the highest blood flow following 5 min of reactive hyperemia. Cardiopulmonary baroreceptor (CPBR) sensitivity was measured using lower body negative pressure (LBNP) for 5 min at -20 mm Hg. CPBR was determined by calculating change of stroke volume and forearm vascular resistance at baseline and during LBNP. Carotid baroreceptor (CBR) sensitivity was assessed using neck suction at -20, -40, -60 and -80 mm Hg pressures, and was determined from RR interval divided by systolic blood pressure. Augmentation index (AIx), a measure of arterial stiffness, was assessed using applanation tonometry and was calculated as the ratio of augmented pressure and pulse pressure. The major findings were that the exercise group showed increase in leg vasodilation, reduction in AIx and increase in VO(2max) compared with the control group (P<0.05). However, there was no significant change for CPBR and CBR. A short-term moderate-intensity aerobic exercise intervention in young men with a family history of hypertension significantly reduced arterial stiffness and increased aerobic fitness.

Indexed as

AdolescentBaroreflexBicyclingBlood PressureBlood VesselsCarotid ArteriesExerciseForearmHumansHyperemiaHypertensionLegLower Body Negative PressureMaleOxygen ConsumptionPressoreceptors

Identifiers

PMID22048712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.