ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Heart rate as an independent risk factor in patients with multiple organ dysfunction: a prospective, observational study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Evaluating the effects of Esmolol on cardiac function in patients with Septic cardiomyopathy by Speck-tracking echocardiography-a randomized controlled trial.BMC anesthesiology · 2023Trial
- Intravenous ivabradine versus placebo in patients with low cardiac output syndrome treated by dobutamine after elective coronary artery bypass surgery: a phase 2 exploratory randomized controlled trial.Critical care (London, England) · 2018Trial
- Early heart-rate trajectory phenotypes predict short-term mortality in critically ill patients: a dynamic time-warping cluster analysis.Journal of clinical monitoring and computing · 2026Article
- Maximum heart rate and mortality in sepsis patients: a retrospective cohort study.Internal and emergency medicine · 2026Article
- Influence of heart rate trajectory in 30-day mortality in sepsis patients: a retrospective study based on the MIMIC-IV database.BMC infectious diseases · 2025Article
- [Septic cardiomyopathy-diagnosis and estimation of disease severity].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
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- Ivabradine in Septic Shock: A Narrative Review.Journal of clinical medicine · 2024Review
- Wearable sensors for prediction of intraamniotic infection in women with preterm premature rupture of membranes: a prospective proof of principle study.Archives of gynecology and obstetrics · 2023Article
- The Association Between Tachycardia and Mortality in Septic Shock Patients According to Serum Lactate Level: A Nationwide Multicenter Cohort Study.Journal of Korean medical science · 2023Article
- Performance of heart rate adjusted heart rate variability for risk stratification of sudden cardiac death.BMC cardiovascular disorders · 2023Article
- Exploring the risk factors of early sepsis after liver transplantation: development of a novel predictive model.Frontiers in medicine · 2023Article
- Sinus Tachycardia: a Multidisciplinary Expert Focused Review.Circulation. Arrhythmia and electrophysiology · 2022Review
- Effects of Music Therapy on Vital Signs in Children with Chronic Disease.International journal of environmental research and public health · 2022Article
- Association between circadian variation of heart rate and mortality among critically ill patients: a retrospective cohort study.BMC anesthesiology · 2022Observational
- Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis-related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study.EClinicalMedicine · 2020Article
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- Novel drugs for heart rate control in heart failure.Heart failure reviews · 2018Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the association between baseline heart rate and outcome in patients with multiple organ dysfunction (MODS) as well as the course of heart rate over the first 4 days during MODS.
methodsProspective observational study in 89 patients with MODS, defined as an APACHE-II score ≥20. Baseline heart rate (HR(0)) was determined over a 60-minute period at the time of MODS diagnosis. 28-day all-cause mortality was the primary endpoint of the study, a fall of the APACHE-II score by 4 points or more from day 0 to day 4 constituted the secondary endpoint. Hazard ratios for heart rate of 90 beats per minute (bpm) or greater relative to less than 90 bpm were calculated using Cox proportional hazards model and adjusted for confounding variables.
resultsMedian baseline heart rate was 83 bpm in survivors and 92 bpm in non-survivors (p = 0.048). 28-day mortality was 32 and 61% in patients with HR(0) < 90 bpm and HR(0) ≥ 90 bpm, respectively. The adjusted hazard ratio for 28-day mortality was 2.30 (95% confidence interval 1.21-4.36, p = 0.001) for HR(0) ≥ 90 bpm relative to HR(0) < 90 bpm. No correlation was found between baseline heart rate and the secondary endpoint. From day 0 to day 4, heart rate remained elevated in all patients, as well as in survivors and non-survivors.
conclusionsA heart rate ≥90 bpm at the time of MODS diagnosis is an independent risk factor for increased 28-day mortality. As in patients with cardiovascular conditions such as coronary heart disease or chronic heart failure, heart rate might constitute a target for heart rate-lowering therapy in the narrow initial treatment window of MODS.
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