ReviewGenes and immunity2012
Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells.
Review in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Gastrointestinal microbiota in treatment of gastric precancerous lesions and gastric cancer by Western and traditional Chinese medicine.World journal of clinical oncology · 2025Review
- The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology.Journal of asthma and allergy · 2025Review
- MiR-125b-5p modulates the function of regulatory T cells in tumor microenvironment by targeting TNFR2.Journal for immunotherapy of cancer · 2022Article
- Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues.Stem cells translational medicine · 2021Article
- The Immune System in Transfusion-Related Acute Lung Injury Prevention and Therapy: Update and Perspective.Frontiers in molecular biosciences · 2021Review
- Article
- Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings.Journal of clinical immunology · 2021Article
- Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin.Archivum immunologiae et therapiae experimentalis · 2020Article
- Intrauterine IPEX.Frontiers in pediatrics · 2020Review
- Article
- Breed-specific differences in the immune response to lipopolysaccharide in ewes.Journal of animal science · 2018Article
- The Imbalance of FOXP3/GATA3 in Regulatory T Cells from the Peripheral Blood of Asthmatic Patients.Journal of immunology research · 2018Article
- Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease.Frontiers in immunology · 2018Review
- TGF-β regulation of encephalitogenic and regulatory T cells in multiple sclerosis.European journal of immunology · 2017Review
- MicroRNAs targeting TGFβ signalling underlie the regulatory T cell defect in multiple sclerosis.Brain : a journal of neurology · 2016Article
- Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.Genes and immunity · 2014Review
- HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.The Journal of clinical investigation · 2014Article
- Special role of Foxp3 for the specifically altered microRNAs in Regulatory T cells of HCC patients.BMC cancer · 2014Article
- Depression in older patients with advanced colorectal cancer is closely connected with immunosuppressive acidic protein.Metabolic brain disease · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD4(+) CD25(+) regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance and homeostasis by limiting aberrant or excessive inflammation. The transcription factor forkhead box P3 (FOXP3) is critical for the development and function of Treg cells. The differentiation of the Treg cell lineage is not terminal, as developmental and functional plasticity occur through the sensing of inflammatory signals in the periphery. Here, we review the recent progress in our understanding of the molecular mechanisms underlying the regulation and functional plasticity of CD4(+) CD25(+) FOXP3(+) Treg cells, through the perturbation of FOXP3 and its complex at a transcriptional, translational and post-translational level.
Indexed as
Identifiers
22048454What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.