Trial reportJournal of anesthesia2012
Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia.
Trial report in Journal of anesthesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance.Phytotherapy research : PTR · 2018Pooled it
- The chronic effects of a combination of herbal extracts (EuphytoseJournal of psychopharmacology (Oxford, England) · 2022Trial
- Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.Medicina oral, patologia oral y cirugia bucal · 2017Trial
- Neuroprotective and Neuromodulatory Potential ofPlants (Basel, Switzerland) · 2026Review
- Chemical Compositions, Pharmacological Properties and Medicinal Effects of GenusPlants (Basel, Switzerland) · 2024Review
- The Anxiolytic Activity ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Natural product-based pharmacological studies for neurological disorders.Frontiers in pharmacology · 2022Review
- Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.Metabolic brain disease · 2020Article
- Herbal Medicinal Products fromTheScientificWorldJournal · 2020Review
- A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol.Integrative medicine research · 2019Article
- Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity.Molecules (Basel, Switzerland) · 2017Review
- Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study.Iranian journal of psychiatry · 2016Article
- Article
- Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.CNS drugs · 2013Review
- Complementary medicine, exercise, meditation, diet, and lifestyle modification for anxiety disorders: a review of current evidence.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients who undergo regional anesthesia experience anxiety in the preoperative period. Passiflora incarnata Linneaus is a plant that has traditionally been used as an anxiolytic and sedative. We aimed to investigate the effect of preoperative oral administration of Passiflora incarnata Linneaus on anxiety, psychomotor functions, sedation, and hemodynamics in patients undergoing spinal anesthesia.
methodsUnder local ethics committee approval, 60 patients who were aged 25-55 years and ASAI-II and who were scheduled for spinal anesthesia were enrolled in this prospective, randomized, double-blind and placebo-controlled study. Thirty minutes before spinal anesthesia, baseline hemodynamic parameters, State-Trait Anxiety Inventory (STAI) score, sedation score, and psychomotor function test results were measured, then patients were randomly assigned to two groups: oral Passiflora incarnata Linneaus extract or placebo was given to the patients. Tests were repeated just before spinal anesthesia. Hemodynamics, sedation score, sensory-motor block and side effects were assessed during the operation. Psychomotor function tests were repeated at the end of the operation and 60 min after the operation.
resultsThere was a statistically significant difference between the two groups for the increase in State Anxiety Inventory (STAI-S) score obtained just before spinal anesthesia when compared to the baseline. There was no statistically significant difference in psychomotor function from the baseline for either group. A significant difference was not found between the two groups in demographics, psychomotor function, sedation score, hemodynamics, and side effects.
conclusionOral preoperative administration of Passiflora incarnata Linneaus suppresses the increase in anxiety before spinal anesthesia without changing psychomotor function test results, sedation level, or hemodynamics.
Indexed as
Identifiers
22048283What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.