ArticleCell death & disease2011
Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset.
Article in Cell death & disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- An uncommon case of concurrent tumors: Unilateral Wilm's tumor with contralateral retroperitoneal teratoma in a 3-year-old child.Urology case reports · 2026Article
- Predicting congenital renal tract malformation genes using machine learning.Scientific reports · 2023Article
- The potential key genes and pathways associated with Wilms tumor in quest of proper candidates for diagnostic and therapeutic purposes.Scientific reports · 2022Review
- Atypical metanephric adenoma: Shares similar histopathological features and molecular changes of metanephric adenoma and epithelial-predominant Wilms' tumor.Frontiers in oncology · 2022Article
- Master Regulators of Epithelial-Mesenchymal Transition and WNT Signaling Pathways in Juvenile Nasopharyngeal Angiofibromas.Biomedicines · 2021Article
- Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).Scientific reports · 2018Article
- Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas.Diagnostic pathology · 2018Article
- Epithelial cells captured from ductal carcinoma in situ reveal a gene expression signature associated with progression to invasive breast cancer.Oncotarget · 2016Article
- IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour.Nature communications · 2014Article
- Early gene expression changes in skeletal muscle from SOD1(G93A) amyotrophic lateral sclerosis animal model.Cellular and molecular neurobiology · 2014Article
- Race disparities in peptide profiles of North American and Kenyan Wilms tumor specimens.Journal of the American College of Surgeons · 2014Article
- CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.Oncotarget · 2014Article
- Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?--A report from the renal tumors biology-driven drug development workshop.Molecular cancer therapeutics · 2013Review
- Wnt pathway activity confers chemoresistance to cancer stem-like cells in a neuroblastoma cell line.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wilms' tumors (WTs) originate from metanephric blastema cells that are unable to complete differentiation, resulting in triphasic tumors composed of epithelial, stromal and blastemal cells, with the latter harboring molecular characteristics similar to those of the earliest kidney development stages. Precise regulation of Wnt and related signaling pathways has been shown to be crucial for correct kidney differentiation. In this study, the gene expression profile of Wnt and related pathways was assessed in laser-microdissected blastemal cells in WTs and differentiated kidneys, in human and in four temporal kidney differentiation stages (i.e. E15.5, E17.5, P1.5 and P7.5) in mice, using an orthologous cDNA microarray platform. A signaling pathway-based gene signature was shared between cells of WT and of earliest kidney differentiation stages, revealing genes involved in the interruption of blastemal cell differentiation in WT. Reverse transcription-quantitative PCR showed high robustness of the microarray data demonstrating 75 and 56% agreement in the initial and independent sample sets, respectively. The protein expression of CRABP2, IGF2, GRK7, TESK1, HDGF, WNT5B, FZD2 and TIMP3 was characterized in WTs and in a panel of human fetal kidneys displaying remarkable aspects of differentiation, which was recapitulated in the tumor. Taken together, this study reveals new genes candidate for triggering WT onset and for therapeutic treatment targets.
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