Evidence map›Paper›PMID 22047981›Full record

ArticleEpilepsy research2012

Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains.

Robert F Hunt, Laura A Haselhorst, Kathleen M Schoch, Eva C Bach, Jennifer Rios-Pilier, Stephen W Scheff, Kathryn E Saatman, Bret N Smith

Abstract readComparative Study
In one paragraph

Article in Epilepsy research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Zolpidem Profoundly Augments Spared Tonic GABAFrontiers in systems neuroscience · 2022
    Article
  5. Animal Models of Post-Traumatic Epilepsy.Diagnostics (Basel, Switzerland) · 2019
    Review
  6. Review
  7. Review
  8. [Effects of embryonic lead exposure on motor function and balance ability in offspring rats and possible mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017
    Article
  9. Article
  10. Animal Models of Posttraumatic Seizures and Epilepsy.Methods in molecular biology (Clifton, N.J.) · 2016
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Neural circuit mechanisms of post-traumatic epilepsy.Frontiers in cellular neuroscience · 2013
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Robert F HuntDepartment of Physiology, University of Kentucky, Lexington, KY 40536-0298, USA.
Laura A Haselhorst
Kathleen M Schoch
Eva C Bach
Jennifer Rios-Pilier
Stephen W Scheff
Kathryn E Saatman
Bret N Smith
University of Kentucky · US

Funding

Role of calpastatin in modulating function following TBIP01NS058484 · NINDS · UNIVERSITY OF KENTUCKY · PI HALL, EDWARD D. · 2007 to 2011
$4.8M
RESPONSE OF THE AGING NERVOUS SYSTEM TO TRAUMAR01AG021981 · NIA · UNIVERSITY OF KENTUCKY · PI SCHEFF, STEPHEN W · 2003 to 2007
$1.8M
Cannabinoid modulation of epileptiform activity in miceR21NS052302 · NINDS · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2005 to 2006
$339k
NIA NIH HHS AG21981NIA NIH HHS R01 AG021981NINDS NIH HHS NS052302NINDS NIH HHS P01 NS058484NINDS NIH HHS R21 NS052302
6 · The paper itself

Abstract

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

Indexed as

AnimalsBrain InjuriesCerebral CortexMiceMice, Inbred C57BLMice, Inbred StrainsMossy Fibers, HippocampalSpecies Specificity

Identifiers

PMID22047981
PMCPMC3290720
OpenAlexW1986800466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.