ArticleAmerican journal of epidemiology2011
Lagging exposure information in cumulative exposure-response analyses.
Article in American journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Radon exposure and risk of cerebrovascular disease: a systematic review and meta-analysis in occupational and general population studies.Environmental science and pollution research international · 2022Pooled it
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- Epidemiological trends of laboratory-confirmed influenza cases driven by meteorological factors in Anhui Province, China: a multi-city time-series analysis.BMC public health · 2025Article
- Site-specific cancer mortality after low-level exposure to ionizing radiation: findings from an update of the International Nuclear Workers Study (INWORKS).American journal of epidemiology · 2025Article
- Leukaemia, lymphoma, and multiple myeloma mortality after low-level exposure to ionising radiation in nuclear workers (INWORKS): updated findings from an international cohort study.The Lancet. Haematology · 2024Article
- Disparities of Heatwave-Related Preterm Birth in Climate Types - China, 2012-2019.China CDC weekly · 2023Article
- Cancer mortality after low dose exposure to ionising radiation in workers in France, the United Kingdom, and the United States (INWORKS): cohort study.BMJ (Clinical research ed.) · 2023Article
- Computed tomography scan radiation and brain cancer incidence.Neuro-oncology · 2023Article
- ESTIMATION AND INFERENCE FOR EXPOSURE EFFECTS WITH LATENCY IN THE COX PROPORTIONAL HAZARDS MODEL IN THE PRESENCE OF EXPOSURE MEASUREMENT ERROR.The annals of applied statistics · 2023Article
- Exposure to Metalworking Fluids and Cancer Incidence in the United Auto Workers-General Motors Cohort.American journal of epidemiology · 2023Article
- Lifetime exposure to rubber dusts, fumes and N-nitrosamines and cancer mortality in a cohort of British rubber workers with 49 years follow-up.Occupational and environmental medicine · 2019Article
- There is no impact of exposure measurement error on latency estimation in linear models.Statistics in medicine · 2019Article
- Site-specific Solid Cancer Mortality After Exposure to Ionizing Radiation: A Cohort Study of Workers (INWORKS).Epidemiology (Cambridge, Mass.) · 2018Article
- Discrepancies on the association between androgen deprivation therapy for prostate cancer and subsequent dementia: meta-analysis and meta-regression.Oncotarget · 2017Article
- Patterns of statin initiation and continuation in patients with breast or colorectal cancer, towards end-of-life.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- Quantifying risk over the life course - latency, age-related susceptibility, and other time-varying exposure metrics.Statistics in medicine · 2016Article
- Risk of cancer from occupational exposure to ionising radiation: retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS).BMJ (Clinical research ed.) · 2015Article
- Glucocorticoid prescriptions and breast cancer recurrence: a Danish nationwide prospective cohort study.Annals of oncology : official journal of the European Society for Medical Oncology · 2014Article
- Using fractional polynomials to model the effect of cumulative duration of exposure on outcomes: applications to cohort and nested case-control designs.Pharmacoepidemiology and drug safety · 2014Article
- Estimating the effect of cumulative occupational asbestos exposure on time to lung cancer mortality: using structural nested failure-time models to account for healthy-worker survivor bias.Epidemiology (Cambridge, Mass.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lagging exposure information is often undertaken to allow for a latency period in cumulative exposure-disease analyses. The authors first consider bias and confidence interval coverage when using the standard approaches of fitting models under several lag assumptions and selecting the lag that maximizes either the effect estimate or model goodness of fit. Next, they consider bias that occurs when the assumption that the latency period is a fixed constant does not hold. Expressions were derived for bias due to misspecification of lag assumptions, and simulations were conducted. Finally, the authors describe a method for joint estimation of parameters describing an exposure-response association and the latency distribution. Analyses of associations between cumulative asbestos exposure and lung cancer mortality among textile workers illustrate this approach. Selecting the lag that maximizes the effect estimate may lead to bias away from the null; selecting the lag that maximizes model goodness of fit may lead to confidence intervals that are too narrow. These problems tend to increase as the within-person exposure variation diminishes. Lagging exposure assignment by a constant will lead to bias toward the null if the distribution of latency periods is not a fixed constant. Direct estimation of latency periods can minimize bias and improve confidence interval coverage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.