ArticlePsychiatry research2011
Cerebellum volume in high-risk offspring from multiplex alcohol dependence families: association with allelic variation in GABRA2 and BDNF.
Article in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth.NeuroImage. Clinical · 2014Pooled it
- Alterations in Neurotrophins in Alcohol-Addicted Patients during Alcohol Withdrawal.Brain sciences · 2024Review
- The collaborative study on the genetics of alcoholism: Brain function.Genes, brain, and behavior · 2023Review
- Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies.Addiction biology · 2023Review
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- Early life adversity and increased antisocial and depressive tendencies in young adults with family histories of alcohol and other substance use disorders: Findings from the Family Health Patterns project.Addictive behaviors reports · 2022Article
- Delay discounting and neurocognitive correlates among inner city adolescents with and without family history of substance use disorder.Developmental cognitive neuroscience · 2021Article
- A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity.Frontiers in behavioral neuroscience · 2019Article
- Does Family History of Alcohol Use Disorder Relate to Differences in Regional Brain Volumes? A Descriptive Review with New Data.Alcoholism, clinical and experimental research · 2018Article
- Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.Addiction biology · 2018Article
- The Cerebellar GABAHandbook of experimental pharmacology · 2018Article
- Genetic variation within GRIN2B in adolescents with alcohol use disorder may be associated with larger left posterior cingulate cortex volume.Acta neuropsychiatrica · 2017Article
- Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.Alcoholism, clinical and experimental research · 2017Article
- Volumetric Differences in Cerebellar Lobes in Individuals from Multiplex Alcohol Dependence Families and Controls: Their Relationship to Externalizing and Internalizing Disorders and Working Memory.Cerebellum (London, England) · 2016Article
- Neurobiological phenotypes associated with a family history of alcoholism.Drug and alcohol dependence · 2016Review
- Psychological and Neurobiological Precursors of Alcohol Use Disorders in High Risk Youth.Current addiction reports · 2015Article
- Advances in Human Neuroconnectivity Research: Applications for Understanding Familial History Risk for Alcoholism.Alcohol research : current reviews · 2015Review
- Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls.Journal of studies on alcohol and drugs · 2015Article
- The cerebellum and addiction: insights gained from neuroimaging research.Addiction biology · 2014Review
- Substance abuse risk in emerging adults associated with smaller frontal gray matter volumes and higher externalizing behaviors.Drug and alcohol dependence · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Offspring from families with multiple cases of alcohol dependence have a greater likelihood of developing alcohol dependence (AD) and related substance use disorders. Greater susceptibility for developing these disorders may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing and AD susceptibility. We examined the cerebellum of 71 adolescent/young adult high-risk (HR) offspring from families with multiple cases of alcohol dependence (multiplex families), and 60 low-risk (LR) controls with no family history of alcohol or drug dependence who were matched for age, gender, socioeconomic status and IQ, with attention given to possible effects of personal use of substances and maternal use during pregnancy. Magnetic resonance images were acquired on a General Electric 1.5-Tesla scanner and manually traced (BRAINS2) blind to clinical information. GABRA2 and BDNF variation were tested for their association with cerebellar volumes. High-risk offspring from multiplex AD families showed greater total volume of the cerebellum and total gray matter (GM), in comparison with LR controls. An interaction between allelic variation in GABRA2 and BDNF genes was associated with GM volumes, suggesting that inherited variation in these genes may promote early developmental differences in neuronal proliferation of the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.