Trial reportPsychiatry research2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder.
Trial report in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prefrontal-limbic circuit modulation in anxiety disorders: Differential neural effects of psychotherapy versus pharmacotherapy revealed by ALE meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Beyond emotions: A meta-analysis of neural response within face processing system in social anxiety.Experimental biology and medicine (Maywood, N.J.) · 2016Pooled it
- Psychological and Physiological Responses in Patients with Generalized Anxiety Disorder: The Use of Acute Exercise and Virtual Reality Environment.International journal of environmental research and public health · 2020Trial
- Autistic eye contact? A hermeneutic phenomenological multicenter study of the similarities and differences in eye-contact experiences between adults with and without autism.Journal of neurodevelopmental disorders · 2025Article
- Increased default mode network activation in depression and social anxiety during upward social comparison.Social cognitive and affective neuroscience · 2025Article
- Variations in the Appearance and Interpretation of Interpersonal Eye Contact in Social Categorizations and Psychiatric Populations Worldwide: A Scoping Review with a Critical Appraisal of the Literature.International journal of environmental research and public health · 2024Article
- Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022Article
- Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity.JAMA network open · 2020Article
- Neural Correlates of Self-referential Processing and Their Clinical Implications in Social Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact.NeuroImage · 2017Article
- The effect of constraining eye-contact during dynamic emotional face perception-an fMRI study.Social cognitive and affective neuroscience · 2017Article
- A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder.Psychiatry research · 2015Article
- Reduced anterior temporal and hippocampal functional connectivity during face processing discriminates individuals with social anxiety disorder from healthy controls and panic disorder, and increases following treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Gaze perception in social anxiety and social anxiety disorder.Frontiers in human neuroscience · 2013Review
- Automatic neural processing of disorder-related stimuli in social anxiety disorder: faces and more.Frontiers in psychology · 2013Article
- Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies.Biological psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Generalized social anxiety disorder (GSAD) is characterized by excessive fears of scrutiny and negative evaluation, but neural circuitry related to scrutiny in GSAD has been little studied. In this study, 16 unmedicated adults with GSAD and 16 matched healthy comparison (HC) participants underwent functional magnetic resonance imaging to assess neural response to viewed images of faces simulating movement into eye contact versus away from eye contact. GSAD patients were then treated for 8 weeks with paroxetine, and 15 patients were re-imaged. At baseline, GSAD patients had elevated neural response to eye contact in parahippocampal cortex, inferior parietal lobule, supramarginal gyrus, posterior cingulate and middle occipital cortex. During paroxetine treatment, symptomatic improvement was associated with decreased neural response to eye contact in regions including inferior and middle frontal gyri, anterior cingulate, posterior cingulate, precuneus and inferior parietal lobule. Both the magnitude of GSAD symptom reduction with paroxetine treatment and the baseline comparison of GSAD vs. HCs were associated with neural processing of eye contact in distributed networks that included regions involved in self-referential processing. These findings demonstrate that eye contact in GSAD engages neurocircuitry consistent with the heightened self-conscious emotional states known to characterize GSAD patients during scrutiny.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.