SynthesisThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2013
Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.
Synthesis in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders.Molecular biology reports · 2026Article
- The prognostic potential of circulating BDNF levels and its polymorphisms in age-related cognitive impairment and neurodegeneration.Frontiers in aging neuroscience · 2026Review
- BDNF Gene Polymorphism and Antidepressant Response in Han Chinese Patients with First-Episode Late-Life Depression.Alpha psychiatry · 2025Article
- An Observational Case-control Study for BDNF Val66Met Polymorphism and Serum BDNF in Patients with Major Depressive Disorder (MDD).Indian journal of psychological medicine · 2024Article
- Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases.Frontiers in neurology · 2024Review
- Genotyping of Macaque Population on the Brain-Derived Neurotrophic Factor Gene Polymorphism by Mismatch Amplification Mutation Assay (MAMA)-PCR.Bulletin of experimental biology and medicine · 2023Article
- [Recent research on the association between depressive disorder and gene polymorphisms in adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Review
- BDNF as a biomarker for neuropathic pain: Consideration of mechanisms of action and associated measurement challenges.Brain and behavior · 2023Review
- Review
- Associations of Plasma BDNF andJournal of nutrition and metabolism · 2023Article
- Exploring the association between brain-derived neurotrophic factor levels and longitudinal psychopathological and cognitive changes in Sardinian psychotic patients.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.Scientific reports · 2021Article
- Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study.Brain, behavior, and immunity · 2021Article
- Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration andJournal of personalized medicine · 2020Article
- Association of the Brain-derived Neurotrophic Factor Val66Met Polymorphism with Body Mass Index, Fasting Glucose Levels and Lipid Status in Adolescents.Balkan journal of medical genetics : BJMG · 2020Article
- The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.Brain communications · 2020Article
- Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients.Frontiers in psychiatry · 2020Article
- Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease.The Indian journal of medical research · 2019Article
- EEG correlates associated with the severity of gambling disorder and serum BDNF levels in patients with gambling disorder.Journal of behavioral addictions · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesLower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS).
methodsIn a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS.
resultsWe estimated the heritability of serum BDNF to be 0.48 from sib-pairs. There was no association between serum BDNF and Val66Met in the SardiNIA sample and in a meta-analysis of published studies (k = 13 studies, total n = 4727, P = 0.92). Although no genome-wide significant associations were identified, some evidence of association was found in the BDNF gene (rs11030102, P = 0.001) and at two loci (rs7170215, P = 4.8 × 10⁻⁵ and rs11073742 P = 1.2 × 10⁻⁵) near and within NTRK3 gene, a neurotrophic tyrosine kinase receptor.
conclusionsOur study and meta-analysis of the literature indicate that the BDNF Val66Met variant is not associated with serum BDNF, but other variants in the BDNF and NTRK3 genes might regulate the level of serum BDNF.
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