ArticleFoodborne pathogens and disease2012
Inhibition of development of Shiga toxin-converting bacteriophages by either treatment with citrate or amino acid starvation.
Article in Foodborne pathogens and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Replication Region Analysis Reveals Non-lambdoid Shiga Toxin Converting Bacteriophages.Frontiers in microbiology · 2021Article
- More than Simple Parasites: the Sociobiology of Bacteriophages and Their Bacterial Hosts.mBio · 2020Review
- Formation of Complexes Between O Proteins and Replication Origin Regions of Shiga Toxin-Converting Bacteriophages.Frontiers in molecular biosciences · 2020Article
- ppGpp and cytotoxicity diversity in Shiga toxin-producing Escherichia coli (STEC) isolates.Epidemiology and infection · 2017Article
- Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action.Scientific reports · 2016Article
- Diminazene aceturate: an antibacterial agent for Shiga-toxin-producingDrug design, development and therapy · 2016Article
- Phenethyl isothiocyanate inhibits shiga toxin production in enterohemorrhagic Escherichia coli by stringent response induction.Antimicrobial agents and chemotherapy · 2014Article
- ppGpp-dependent negative control of DNA replication of Shiga toxin-converting bacteriophages in Escherichia coli.Journal of bacteriology · 2013Article
- Genes from the exo-xis region of λ and Shiga toxin-converting bacteriophages influence lysogenization and prophage induction.Archives of microbiology · 2013Article
- Altruism of Shiga toxin-producing Escherichia coli: recent hypothesis versus experimental results.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesShiga toxin-producing Escherichia coli (STEC) are pathogenic strains, whose virulence depends on induction of Shiga toxin-converting prophages and their subsequent lytic development. We explored which factors or conditions could inhibit development of these phages, potentially decreasing virulence of STEC. MATERIALS AND
methodsLytic development of Shiga toxin-converting bacteriophages was monitored after mitomycin C-provoked prophage induction under various conditions. Phage DNA replication efficiency was assessed by measurement of DNA amount in cells using quantitative polymerase chain reaction.
resultsWe demonstrated that the use of citrate delayed Shiga toxin-converting phage development after prophage induction. This effect was independent on efficiency of prophage induction and phage DNA replication. However, an excess of glucose reversed the effect of citrate. Amino acid starvation prevented the phage development in bacteria both able and unable to induce the stringent response.
conclusionsLytic development of Shiga toxin-converting bacteriophages can be inhibited by either the presence of citrate or amino acid starvation. We suggest that the inhibition caused by the latter condition may be due to a block in prophage induction or phage DNA replication or both. APPLICATIONS: Our findings may facilitate development of procedures for treatment of STEC-infected patients.
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