ArticleBMC microbiology2011
Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 192 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mirabegron and Urinary Urgency Incontinence: The Clinical Response and the Female Urinary Microbiome
The Effects of Vaginal Estrogen and a Nonhormonal Alternative on the Vaginal and Urinary Microbiome in Women With Genitourinary Syndrome of Menopause: A Randomized Controlled Trial
Urinary Microbiome Changes Following Administration of 500 mg of NDS-446 in Women With Dry OAB at 12 Weeks - a Single-center Study
Investigation of the Effects of Local Estrogen Administration on Vaginal, Periurethral and Urinary Microbiota in Genitourinary Syndrome
Who cites it
192 citing papers in PubMed, 1 synthesis or guideline pooled it, 333 citations in OpenAlex.
- Uncovering the role of urinary microbiota in urological tumors: a systematic review of literature.World journal of urology · 2022Pooled it
- The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment.Microbiome · 2017Trial
- Methodology for a vaginal and urinary microbiome study in women with mixed urinary incontinence.International urogynecology journal · 2017Trial
- Urinary catheter-associated microbiota change in accordance with treatment and infection status.PloS one · 2017Trial
- Urinary bacteria in adult women with urgency urinary incontinence.International urogynecology journal · 2014Trial
- Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review).International journal of molecular medicine · 2026Review
- Occurrence and relevance of Gardnerella vaginalis in urine cultures of kidney transplant recipients- a retrospective cohort analysis.BMC microbiology · 2026Article
- Urinary microbiome in renal transplant patients with BK polyomavirus reactivation.Journal of medical microbiology · 2026Article
- Genome sequence ofMicrobiology resource announcements · 2026Article
- The urinary microbiome, overactive bladder and bladder pain syndrome/interstitial cystitis - mechanisms, diagnostics and therapeutic opportunities.Nature reviews. Urology · 2026Review
- Underexplored maternal microbiomes: immune, metabolic, and microbial pathways shaping pregnancy outcomes.Infection and immunity · 2026Review
- The stone-degrading metabolic potential of the urinary microbiome: Sexual dimorphism and dysbiosis in urolithiasis.AIMS microbiology · 2026Article
- Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects.Frontiers in cellular and infection microbiology · 2026Review
- Urinary Microbiota in Female Patients With Dry and Wet Overactive Bladder (OAB).International journal of genomics · 2026Article
- Biomarkers innovation in urinary tract infections: Insights into pathophysiology, antibiotic resistance, and clinical applications.World journal of nephrology · 2025Review
- Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection.NPJ biofilms and microbiomes · 2025Article
- The Urinary Microbiota and the Gut-Bladder Axis in Bladder Cancer.International journal of molecular sciences · 2025Review
- Urobiome Signatures of Recurrent Urinary Tract Infections in Adolescent Pregnancy: A Longitudinal Study.Microorganisms · 2025Article
- Urinary microbiome in non-muscle invasive bladder cancer: impact of sample types and sex differences.BMC microbiology · 2025Article
- Role of UropathogenicPathogens (Basel, Switzerland) · 2025Review
132 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrine within the urinary tract is commonly regarded as "sterile" in cultivation terms. Here, we present a comprehensive in-depth study of bacterial 16S rDNA sequences associated with urine from healthy females by means of culture-independent high-throughput sequencing techniques.
resultsSequencing of the V1V2 and V6 regions of the 16S ribosomal RNA gene using the 454 GS FLX system was performed to characterize the possible bacterial composition in 8 culture-negative (<100,000 CFU/ml) healthy female urine specimens. Sequences were compared to 16S rRNA databases and showed significant diversity, with the predominant genera detected being Lactobacillus, Prevotella and Gardnerella. The bacterial profiles in the female urine samples studied were complex; considerable variation between individuals was observed and a common microbial signature was not evident. Notably, a significant amount of sequences belonging to bacteria with a known pathogenic potential was observed. The number of operational taxonomic units (OTUs) for individual samples varied substantially and was in the range of 20-500.
conclusionsNormal female urine displays a noticeable and variable bacterial 16S rDNA sequence richness, which includes fastidious and anaerobic bacteria previously shown to be associated with female urogenital pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.