ArticleAmerican journal of translational research2011
Translational research: current status, challenges and future strategies.
Article in American journal of translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Molecular carcinogenesis and genetic insights in leiomyosarcoma: involvement of PI3K/AKT/mTOR/MAPK/ERK pathway.American journal of cancer research · 2026Review
- Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy.Clinical epigenetics · 2025Review
- Predicting clinical trial success forFrontiers in artificial intelligence · 2024Article
- Climbing behavior by mice as an endpoint for preclinical assessment of drug effects in the absence and presence of pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Exploring the translational challenge for medical applications of ionising radiation and corresponding radiation protection research.Journal of translational medicine · 2022Article
- Confronting the challenge of failed translation in medications development for substance use disorders.Pharmacology, biochemistry, and behavior · 2021Article
- The 3Rs Principle in Animal Experimentation: A Legal Review of the State of the Art in Europe and the Case in Italy.Biotech (Basel (Switzerland)) · 2021Article
- Brain oxytocin: how puzzle stones from animal studies translate into psychiatry.Molecular psychiatry · 2021Review
- A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter.Frontiers in pharmacology · 2021Article
- Translational research in biomedical sciences in India: Challenges, observations & national perspectives.The Indian journal of medical research · 2020Article
- Pharmacological validation of a translational model of cocaine use disorder: Effects of d-amphetamine maintenance on choice between intravenous cocaine and a nondrug alternative in humans and rhesus monkeys.Experimental and clinical psychopharmacology · 2020Article
- Joining forces: the need to combine science and ethics to address problems of validity and translation in neuropsychiatry research using animal models.Philosophy, ethics, and humanities in medicine : PEHM · 2020Article
- Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.Pharmacological reviews · 2019Review
- Awareness of and attitudes toward translational medicine among health personnel in hospitals in Shanghai, China.The Journal of international medical research · 2019Article
- Development of a translational model to screen medications for cocaine use disorder I: Choice between cocaine and food in rhesus monkeys.Drug and alcohol dependence · 2016Article
- Reply to Fiscella: The phases of biomedical research should be studied to optimize health outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Model of translational cancer research in multiple myeloma.Cancer science · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in translational research are expected to mitigate the recent drought in new drug development. Despite significant progress recently made in biological sciences, the results are decidedly mixed with significant breakthrough in some disease areas while extensive work remains to be completed in other areas. This review article provides a general survey of the current landscape of translational research so as to identify progress and areas of needs and the associated strategy. While significant advances in the development of translational tools have been made in all fronts, the availability of predictive preclinical models remains critical for the success of translational research. This is directly correlated with the success of translational research as illustrated by the recent approval of targeted drug therapies. By the same logic, unexpected side effects can also be explained by laboratory findings, thus completing the translational cycle. Because of this reason, further collaboration between preclinical and clinical scientists is essential. Non-scientific issues have important influence on the future of this endeavor cannot be underestimated either. Nonetheless, with definitive commitment of private industry and public resources, the future of translational research is promising.
Indexed as
Identifiers
22046484PMC3204888What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.