ArticlePloS one2011
Responses of peripheral blood flow to acute hypoxia and hyperoxia as measured by optical microangiography.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Measuring and imaging of transcutaneous bilirubin, hemoglobin, and melanin based on diffuse reflectance spectroscopy.Journal of biomedical optics · 2023Article
- Sympathetic neurovascular transduction following acute hypoxia.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Effects of weather and season on human brain volume.PloS one · 2021Article
- Effects of Normoxia, Hyperoxia, and Mild Hypoxia on Macro-Hemodynamics and the Skeletal Muscle Microcirculation in Anesthetised Rats.Frontiers in medicine · 2021Article
- Regenerated Microvascular Networks in Ischemic Skeletal Muscle.Frontiers in physiology · 2021Article
- Article
- Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.Journal of neurosurgery · 2014Article
- Label-free imaging of blood vessel morphology with capillary resolution using optical microangiography.Quantitative imaging in medicine and surgery · 2012Article
- Impact of intraocular pressure on changes of blood flow in the retina, choroid, and optic nerve head in rats investigated by optical microangiography.Biomedical optics express · 2012Article
- Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility.Biomedical optics express · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Oxygen availability is regarded as a critical factor to metabolically regulate systemic blood flow. There is a debate as to how peripheral blood flow (PBF) is affected and modulated during hypoxia and hyperoxia; however in vivo evaluating of functional PBF under oxygen-related physiological perturbation remains challenging. Microscopic observation, the current frequently used imaging modality for PBF characterization often involves the use of exogenous contrast agents, which would inevitably perturb the intrinsic physiologic responses of microcirculation being investigated. In this paper, optical micro-angiography (OMAG) was employed that uses intrinsic optical scattering signals backscattered from blood flows for imaging PBF in skeletal muscle challenged by the alteration of oxygen concentration. By utilizing optical reflectance signals, we demonstrated that OMAG is able to show the response of hemodynamic activities upon acute hypoxia and hyperoxia, including the modulation of macrovascular caliber, microvascular density, and flux regulation within different sized vessels within skeletal muscle in mice in vivo. Our results suggest that OMAG is a promising tool for in vivo monitoring of functional macro- or micro-vascular responses within peripheral vascular beds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.