ArticlePloS one2011
Evidence for retrogene origins of the prion gene family.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Probing the origin of prion protein misfolding via reconstruction of ancestral proteins.Protein science : a publication of the Protein Society · 2022Article
- RNA as the stone guest of protein aggregation.Nucleic acids research · 2020Review
- COVID-19 and iron dysregulation: distant sequence similarity between hepcidin and the novel coronavirus spike glycoprotein.Biology direct · 2020Article
- Article
- Conservation of Prion-Like Composition and Sequence in Prion-Formers and Prion-Like Proteins ofFrontiers in molecular biosciences · 2019Article
- Evolutionary behaviour of bacterial prion-like proteins.PloS one · 2019Article
- Prion gene paralogs are dispensable for early zebrafish development and have nonadditive roles in seizure susceptibility.The Journal of biological chemistry · 2018Article
- A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.Scientific reports · 2017Article
- Review
- The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis.PloS one · 2015Article
- Biochemical insight into the prion protein family.Frontiers in cell and developmental biology · 2015Review
- The structure of human prions: from biology to structural models-considerations and pitfalls.Viruses · 2014Review
- An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition.Frontiers in cell and developmental biology · 2014Article
- The prion protein family: a view from the placenta.Frontiers in cell and developmental biology · 2014Review
- Reliability of the nanopheres-DNA immunization technology to produce polyclonal antibodies directed against human neogenic proteins.Molecular genetics and genomics : MGG · 2013Article
- The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.PloS one · 2013Article
- LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.Journal of molecular biology · 2012Article
- Biphasic patterns of diversification and the emergence of modules.Frontiers in genetics · 2012Article
- Review
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Authors and funding
6 authors.
Funding
Abstract
The evolutionary origin of prion genes, only known to exist in the vertebrate lineage, had remained elusive until recently. Following a lead from interactome investigations of the murine prion protein, our previous bioinformatic analyses revealed the evolutionary descent of prion genes from an ancestral ZIP metal ion transporter. However, the molecular mechanism of evolution remained unexplored. Here we present a computational investigation of this question based on sequence, intron-exon, synteny and pseudogene analyses. Our data suggest that during the emergence of metazoa, a cysteine-flanked core domain was modularly inserted, or arose de novo, in a preexisting ZIP ancestor gene to generate a prion-like ectodomain in a subbranch of ZIP genes. Approximately a half-billion years later, a genomic insertion of a spliced transcript coding for such a prion-like ZIP ectodomain may have created the prion founder gene. We document that similar genomic insertions involving ZIP transcripts, and probably relying on retropositional elements, have indeed occurred more than once throughout evolution.
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