ArticlePloS one2011
Epigenetic changes with dietary soy in cynomolgus monkeys.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health.Journal of physiology and biochemistry · 2025Review
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
- Role of epigenetic in cancer biology, in hematologic malignancies and in anticancer therapy.Frontiers in molecular medicine · 2024Review
- Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease.Frontiers in pharmacology · 2023Review
- Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health.Antioxidants (Basel, Switzerland) · 2021Review
- The Role of Isoflavones in Type 2 Diabetes Prevention and Treatment-A Narrative Review.International journal of molecular sciences · 2020Review
- Use of the Illumina EPIC methylation array for epigenomic research in the crab-eating macaque (Macaca fascicularis).Neuropsychopharmacology reports · 2020Article
- Maternal exposure to soy diet reduces atheroma in hyperlipidemic F1 offspring mice by promoting macrophage and T cell anti-inflammatory responses.Atherosclerosis · 2020Article
- Dietary inclusion of plant ingredients induces epigenetic changes in the intestine of zebrafish.Epigenetics · 2020Article
- Review
- Mislocalization of Runt-related transcription factor 3 results in airway inflammation and airway hyper-responsiveness in a murine asthma model.Experimental and therapeutic medicine · 2017Article
- Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells.The Journal of biological chemistry · 2017Article
- Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms.Advances in nutrition (Bethesda, Md.) · 2016Review
- Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons.Frontiers in nutrition · 2016Article
- Therapeutic perspectives of epigenetically active nutrients.British journal of pharmacology · 2015Review
- Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men.Epigenetics · 2015Article
- Impact of soy isoflavones on the epigenome in cancer prevention.Nutrients · 2014Review
- Infinium monkeys: Infinium 450K array for the Cynomolgus macaque (Macaca fascicularis).G3 (Bethesda, Md.) · 2014Article
- A hypothesis regarding the molecular mechanism underlying dietary soy-induced effects on seizure propensity.Frontiers in neurology · 2014Review
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Nutritional interventions are important alternatives for reducing the prevalence of many chronic diseases. Soy is a good source of protein that contains isoflavones, including genistein and daidzein, and may alter the risk of obesity, Type 2 diabetes, osteoporosis, cardiovascular disease, and reproductive cancers. We have shown previously in nonhuman primates that soy protein containing isoflavones leads to improved body weight, insulin sensitivity, lipid profiles, and atherosclerosis compared to protein without soy isoflavones (casein), and does not increase the risk of cancer. Since genistein has been shown to alter DNA methylation, we compared the methylation profiles of cynomolgus monkeys, from multiple tissues, eating two high-fat, typical American diets (TAD) with similar macronutrient contents, with or without soy protein. DNA methylation status was successfully determined for 80.6% of the probes in at least one tissue using Illumina's HumanMethylation27 BeadChip. Overall methylation increased in liver and muscle tissue when monkeys switched from the TAD-soy to the TAD-casein diets. Genes involved in epigenetic processes, specifically homeobox genes (HOXA5, HOXA11, and HOXB1), and ABCG5 were among those that changed between diets. These data support the use of the HumanMethylation27 BeadChip in cynomolgus monkeys and identify epigenetic changes associated with dietary interventions with soy protein that may potentially affect the etiology of complex diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.