ArticlePloS one2011
Parallel evolution of KCNQ4 in echolocating bats.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 61 citations in OpenAlex.
- Gene Ontology-Based Comparative Transcriptomics Provides Evidence of Genetic Adaptations in theAnimals : an open access journal from MDPI · 2026Article
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Single-Cell Landscape of the Cochlea Revealed Cell-Type-Specific Diversification inBiomolecules · 2025Article
- Cloning, characterization, and evolutionary patterns ofEcology and evolution · 2024Article
- Molecular adaptations underlying high-frequency hearing in the brain of CF bats species.BMC genomics · 2024Article
- Musculoskeletal morphogenesis supports the convergent evolution of bat laryngeal echolocation.Proceedings. Biological sciences · 2024Article
- Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats.iScience · 2022Article
- Comparative transcriptome analysis provides insights into the molecular mechanisms of high-frequency hearing differences between the sexes of Odorrana tormota.BMC genomics · 2022Article
- Assessing evidence for adaptive evolution in two hearing-related genes important for high-frequency hearing in echolocating mammals.G3 (Bethesda, Md.) · 2021Article
- Evidence of Echolocation in the Common Shrew from Molecular Convergence with Other Echolocating Mammals.Zoological studies · 2020Article
- Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics.Genome biology and evolution · 2020Article
- A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- As Blind as a Bat? Opsin Phylogenetics Illuminates the Evolution of Color Vision in Bats.Molecular biology and evolution · 2019Article
- Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales.Science advances · 2018Article
- Testing Convergent Evolution in Auditory Processing Genes between Echolocating Mammals and the Aye-Aye, a Percussive-Foraging Primate.Genome biology and evolution · 2017Article
- Article
- Are Convergent and Parallel Amino Acid Substitutions in Protein Evolution More Prevalent Than Neutral Expectations?Molecular biology and evolution · 2015Article
- No genome-wide protein sequence convergence for echolocation.Molecular biology and evolution · 2015Article
- Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals.Proceedings. Biological sciences · 2014Article
- The glycogen synthase 2 gene (Gys2) displays parallel evolution between Old World and New World fruit bats.Journal of molecular evolution · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-frequency hearing is required for echolocating bats to locate, range and identify objects, yet little is known about its molecular basis. The discovery of a high-frequency hearing-related gene, KCNQ4, provides an opportunity to address this question. Here, we obtain the coding regions of KCNQ4 from 15 species of bats, including echolocating bats that have higher frequency hearing and non-echolocating bats that have the same ability as most other species of mammals. The strongly supported protein-tree resolves a monophyletic group containing all bats with higher frequency hearing and this arrangement conflicts with the phylogeny of bats in which these species are paraphyletic. We identify five parallel evolved sites in echolocating bats belonging to both suborders. The evolutionary trajectories of the parallel sites suggest the independent gain of higher frequency hearing ability in echolocating bats. This study highlights the usefulness of convergent or parallel evolutionary studies for finding phenotype-related genes and contributing to the resolution of evolutionary problems.
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