ArticlePloS one2011
Genomotyping of Coxiella burnetii using microarrays reveals a conserved genomotype for hard tick isolates.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- From Q Fever to Coxiella burnetii Infection: a Paradigm Change.Clinical microbiology reviews · 2017Review
- The bacterial pangenome as a new tool for analysing pathogenic bacteria.New microbes and new infections · 2015Article
- DNA microarray-based detection of Coxiella burnetii, the causative agent of Q fever.Acta veterinaria Scandinavica · 2014Article
- When outgroups fail; phylogenomics of rooting the emerging pathogen, Coxiella burnetii.Systematic biology · 2013Article
- Q fever and pregnancy: disease, prevention, and strain specificity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- In vitro and in vivo infectious potential of coxiella burnetii: a study on Belgian livestock isolates.PloS one · 2013Article
- Genome sequence of Coxiella burnetii 109, a doxycycline-resistant clinical isolate.Journal of bacteriology · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C. burnetii is a Gram-negative intracellular Y-proteobacteria that causes the zoonotic disease Q fever. Q fever can manifest as an acute or chronic illness. Different typing methods have been previously developed to classify C. burnetii isolates to explore its pathogenicity. Here, we report a comprehensive genomotyping method based on the presence or absence of genes using microarrays. The genomotyping method was then tested in 52 isolates obtained from different geographic areas, different hosts and patients with different clinical manifestations. The analysis revealed the presence of 10 genomotypes organized into 3 groups, with a topology congruent with that obtained through multi-spacer typing. We also found that only 4 genomotypes were specifically associated with acute Q fever, whereas all of the genomotypes could be associated to chronic human infection. Serendipitously, the genomotyping results revealed that all hard tick isolates, including the Nine Mile strain, belong to the same genomotype.
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