SynthesisPloS one2011
Impact of genetic variation in SORCS1 on memory retention.
Synthesis in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer's disease.Molecular neurodegeneration · 2022Pooled it
- Genetic variants and cognitive functions in patients with brain tumors.Neuro-oncology · 2019Article
- Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Molecular neurobiology · 2018Review
- Retromer Dysfunction and Neurodegenerative Disease.Current genomics · 2018Review
- The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Molecular genetics and genomics : MGG · 2015Review
- SORCS1 contributes to the development of renal disease in rats and humans.Physiological genomics · 2013Article
- Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).Translational psychiatry · 2013Article
- Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- New insights into the genetic mechanism of IQ in autism spectrum disorders.Frontiers in genetics · 2013Article
- The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population.PloS one · 2013Article
- Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Review
- The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.Future neurology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe previously reported that genetic variants in SORCS1 increase the risk of AD, that over-expression of SorCS1 reduces γ-secretase activity and Aβ levels, and that SorCS1 suppression increases γ-secretase processing of APP and Aβ levels. We now explored the effect of variation in SORCS1 on memory.
methodsWe explored associations between SORCS1-SNPs and memory retention in the NIA-LOAD case control dataset (162 cases,670 controls) and a cohort of Caribbean Hispanics (549 cases,544 controls) using single marker and haplotype analyses.
resultsThree SNPs in intron 1, were associated with memory retention in the NIA-LOAD dataset or the Caribbean Hispanic dataset (rs10884402(A allele:β = -0.15,p = 0.008), rs7078098(C allele:β = 0.18,p = 0.007) and rs950809(C allele:β = 0.17,p = 0.008)) and all three SNPs were significant in a meta-analysis of both datasets (0.002<p<0.03). The corresponding A-T-T haplotype for these SNPs was associated with lower scores in both datasets (p = 0.02,p = 0.0009), and the complementary G-C-C haplotype was associated with higher scores in NIA-LOAD (p = 0.02). These associations were restricted to cases.
conclusionsVariation in intron 1 in SORCS1 is associated with memory changes in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.