ArticlePLoS computational biology2011
Metabolic regulation in progression to autoimmune diabetes.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 91 citations in OpenAlex.
- Longitudinal monitoring of type 1 diabetes progression to disease onset.Science advances · 2026Article
- LC-MS-based conventional metabolomics combined with machine learning models to identify metabolic markers for the diagnosis of type I diabetes.Frontiers in endocrinology · 2025Article
- The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease.Molecular medicine (Cambridge, Mass.) · 2023Review
- Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications.International journal of molecular sciences · 2023Review
- Glucose metabolic reprogramming in autoimmune diseases.Animal cells and systems · 2023Review
- Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Untargeted metabolomics reveals gender- and age- independent metabolic changes of type 1 diabetes in Chinese children.Frontiers in endocrinology · 2022Article
- Application of Differential Network Enrichment Analysis for Deciphering Metabolic Alterations.Metabolites · 2020Article
- Review
- Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR.PloS one · 2020Article
- Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice.Diabetologia · 2019Article
- Metabolomics of Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2019Review
- Association of prevalent vaginal microbiome of mother with occurrence of type I diabetes in child.Scientific reports · 2019Article
- PRWHMDA: Human Microbe-Disease Association Prediction by Random Walk on the Heterogeneous Network with PSO.International journal of biological sciences · 2018Article
- Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders.Mediators of inflammation · 2018Review
- Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.Journal of proteome research · 2017Article
- Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset.Diabetes · 2017Article
- Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis.Diabetologia · 2017Article
- Elevated systemic glutamic acid level in the non-obese diabetic mouse is Idd linked and induces beta cell apoptosis.Immunology · 2017Article
- Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design of the human study and derived the metabolic states from longitudinal lipidomics data. We show that female NOD mice who later progress to autoimmune diabetes exhibit the same lipidomic pattern as prediabetic children. These metabolic changes are accompanied by enhanced glucose-stimulated insulin secretion, normoglycemia, upregulation of insulinotropic amino acids in islets, elevated plasma leptin and adiponectin, and diminished gut microbial diversity of the Clostridium leptum group. Together, the findings indicate that autoimmune diabetes is preceded by a state of increased metabolic demands on the islets resulting in elevated insulin secretion and suggest alternative metabolic related pathways as therapeutic targets to prevent diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.