ArticlePLoS computational biology2011
Conformation regulation of the X chromosome inactivation center: a model.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism ofbioRxiv : the preprint server for biology · 2026Article
- Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells.Biophysics and physicobiology · 2022Article
- Modeling the 3D genome of plants.Nucleus (Austin, Tex.) · 2021Article
- The Interplay between Phase Separation and Gene-Enhancer Communication: A Theoretical Study.Biophysical journal · 2020Article
- Predicting Genome Architecture: Challenges and Solutions.Frontiers in genetics · 2020Review
- Polymer physics predicts the effects of structural variants on chromatin architecture.Nature genetics · 2018Article
- Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells.Nature structural & molecular biology · 2017Article
- Predicting chromatin architecture from models of polymer physics.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Review
- Structure of the human chromosome interaction network.PloS one · 2017Article
- A Polymer Physics Investigation of the Architecture of the Murine Orthologue of theFrontiers in neuroscience · 2017Review
- Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization.Scientific reports · 2016Article
- A self-enhanced transport mechanism through long noncoding RNAs for X chromosome inactivation.Scientific reports · 2016Article
- Chromatin topology is coupled to Polycomb group protein subnuclear organization.Nature communications · 2016Article
- Physical mechanisms behind the large scale features of chromatin organization.Transcription · 2014Review
- Article
- Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.Nucleic acids research · 2013Article
- Polymer models of chromatin organization.Frontiers in genetics · 2013Article
- Colocalization of multiple DNA loci: a physical mechanism.Biophysical journal · 2012Article
- A polymer model explains the complexity of large-scale chromatin folding.Nucleus (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-Chromosome Inactivation (XCI) is the process whereby one, randomly chosen X becomes transcriptionally silenced in female cells. XCI is governed by the Xic, a locus on the X encompassing an array of genes which interact with each other and with key molecular factors. The mechanism, though, establishing the fate of the X's, and the corresponding alternative modifications of the Xic architecture, is still mysterious. In this study, by use of computer simulations, we explore the scenario where chromatin conformations emerge from its interaction with diffusing molecular factors. Our aim is to understand the physical mechanisms whereby stable, non-random conformations are established on the Xic's, how complex architectural changes are reliably regulated, and how they lead to opposite structures on the two alleles. In particular, comparison against current experimental data indicates that a few key cis-regulatory regions orchestrate the organization of the Xic, and that two major molecular regulators are involved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.