Evidence map›Paper›PMID 22046003›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011

The biology of aging: 1985-2010 and beyond.

George M Martin

Erratum issuedAbstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Se-EnrichedAntioxidants (Basel, Switzerland) · 2023
    Article
  3. Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. DNA Damage, DNA Repair, Aging, and Neurodegeneration.Cold Spring Harbor perspectives in medicine · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

1 author.

George M MartinDepartments of Pathology and Genome Sciences, University of Washington, Seattle, Washington, 98195-7470, USA. gmmartin@uw.edu

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
INTERNATIONAL REGISTRY OF WERNER SYNDROME/CELL BANKR24CA078088 · NCI · UNIVERSITY OF WASHINGTON · PI MARTIN, GEORGE M. · 1997 to 2011
$2.1M
dementias of the Alzheimer's TypeR01AG019711 · NIA · UNIVERSITY OF WASHINGTON · PI MARTIN, GEORGE M. · 2001 to 2005
$1.6M
NCI NIH HHS R24 CA078088NCI NIH HHS R24CA078088NIA NIH HHS P01 AG001751NIA NIH HHS P01AG001751NIA NIH HHS R01 AG019711NIA NIH HHS R01AG019711
6 · The paper itself

Abstract

In this contribution to the series of reflective essays celebrating the 25th anniversary of The FASEB Journal, our task is to assess the growth of research on the biology of aging during this period and to suggest where we might be heading during the next 25 yr. A review of the literature suggests a healthy acceleration of progress during the past decade, perhaps largely due to progress on the genetics of longevity of model organisms. Progress on the genetics of health span in these model organisms has lagged, however. Research on the genetic basis of the remarkable interspecific variations in life span has only recently begun to be seriously addressed. The spectacular advances in genomics should greatly accelerate progress. Research on environmental effects on life span and health span needs to be accelerated. Stochastic variations in gene expression in aging have only recently been addressed. These can lead to random departures from homeostasis during aging.-Martin, G. M. The biology of aging: 1985-2010 and beyond.

Indexed as

AgingAnimalsCaenorhabditis elegansCaloric RestrictionDrosophila melanogasterEpigenesis, GeneticFree RadicalsGene ExpressionHumansLife ExpectancyLongevityMiceMitochondriaRegenerative MedicineResveratrolStem CellsFree RadicalsResveratrolStilbenesTelomerase

Identifiers

PMID22046003
PMCPMC4050331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.