ArticleThe Journal of biological chemistry2012
Identification of a new fatty acid synthesis-transport machinery at the peroxisomal membrane.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Mitochondrial dysfunction triggers a maladaptive peroxisomal response driving lipid accumulation.Redox biology · 2026Article
- Article
- Label-Free Quantitative Proteomics Analysis of Adriamycin Selected Multidrug Resistant Human Lung Cancer Cells.Biomolecules · 2022Article
- Role of fatty acid transport protein 4 in metabolic tissues: insights into obesity and fatty liver disease.Bioscience reports · 2022Review
- Peroxisomal ABC Transporters: An Update.International journal of molecular sciences · 2021Review
- Bioactive Ether Lipids: Primordial Modulators of Cellular Signaling.Metabolites · 2021Review
- Hepatic transcriptome analysis identifies genes, polymorphisms and pathways involved in the fatty acids metabolism in sheep.PloS one · 2021Article
- Edgetic Perturbations Contribute to Phenotypic Variability in PEX26 Deficiency.Frontiers in genetics · 2021Article
- Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice.Scientific reports · 2020Article
- Fatty Acid Synthase: An Emerging Target in Cancer.Molecules (Basel, Switzerland) · 2020Review
- Article
- Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy.Medicine · 2018Article
- Structural and functional roles of ether lipids.Protein & cell · 2018Review
- Spatial Organization of Metabolic Enzyme Complexes in Cells.Biochemistry · 2017Review
- Peroxisomal ATP-binding cassette transporters form mainly tetramers.The Journal of biological chemistry · 2017Article
- C13orf31 (FAMIN) is a central regulator of immunometabolic function.Nature immunology · 2016Article
- How to move an amphipathic molecule across a lipid bilayer: different mechanisms for different ABC transporters?Biochemical Society transactions · 2016Review
- Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.Cell metabolism · 2015Article
- Peroxisomes: a nexus for lipid metabolism and cellular signaling.Cell metabolism · 2014Review
- Fatty acid transporters in skin development, function and disease.Biochimica et biophysica acta · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurodegenerative disease X-linked adrenoleukodystrophy (X-ALD) is characterized by the abnormal accumulation of very long chain fatty acids. Mutations in the gene encoding the peroxisomal ATP-binding cassette half-transporter, adrenoleukodystrophy protein (ALDP), are the primary cause of X-ALD. To gain a better understanding of ALDP dysfunction, we searched for interaction partners of ALDP and identified binary interactions to proteins with functions in fatty acid synthesis (ACLY, FASN, and ACC) and activation (FATP4), constituting a thus far unknown fatty acid synthesis-transport machinery at the cytoplasmic side of the peroxisomal membrane. This machinery adds to the knowledge of the complex mechanisms of peroxisomal fatty acid metabolism at a molecular level and elucidates potential epigenetic mechanisms as regulatory processes in the pathogenesis and thus the clinical course of X-ALD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.